Chelating agent

This page covers all Chelating agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Divalent metal cations (Pb²⁺, Cd²⁺, Ca²⁺, Zn²⁺), Heavy metal ions (lead, cadmium, zinc, and other divalent/trivalent cations), Calcium ions and divalent cations in mineralized tooth structure.

Targets

Divalent metal cations (Pb²⁺, Cd²⁺, Ca²⁺, Zn²⁺) · Heavy metal ions (lead, cadmium, zinc, and other divalent/trivalent cations) · Calcium ions and divalent cations in mineralized tooth structure · Heavy metal ions (copper, mercury, lead); thiol-reactive compounds · Copper

Marketed (3)

• disodium EDTA · Mt. Sinai Medical Center, Miami · Toxicology / Nephrology
  Disodium EDTA is a chelating agent that binds and removes heavy metals and excess divalent cations from the bloodstream.
• Edetate Calcium Disodium · M.D. Anderson Cancer Center · Toxicology
  Edetate calcium disodium is a chelating agent that binds and removes heavy metals (particularly lead) from the body by forming stable complexes that are excreted in urine.
• EDTA root conditioning · Ain Shams University · Dentistry / Endodontics
  EDTA (ethylenediaminetetraacetic acid) chelates calcium and other divalent cations in root surfaces to remove the smear layer and condition dentin for improved adhesion in endodontic and restorative procedures.

Phase 3 pipeline (1)

• Penicillamine (D1-W12) · Orphalan · Rare disease / Metabolic disorder
  Penicillamine is a chelating agent that binds to heavy metals and promotes their urinary excretion, reducing toxic metal accumulation in tissues.

Phase 2 pipeline (1)

• Bis-Choline Tetrathiomolybdate · Alexion Pharmaceuticals, Inc. · Neurology
  Bis-Choline Tetrathiomolybdate is a chelating agent that binds to copper, reducing its availability for incorporation into ceruloplasmin and subsequent deposition in the brain.