What are Botulinum toxin type A drugs?

Botulinum toxin type A drugs are pharmacologic agents that share a common mechanism (typically targeting SNAP-25 (synaptosome-associated protein of 25 kDa)). 9 are currently marketed, with 9 more in clinical development.

What are the marketed Botulinum toxin type A drugs?

Marketed Botulinum toxin type A drugs include Botox Cosmetic™, incabotulinumtoxinA, Xeomin®, NT 201, Azzalure or Dysport, NAFT500 (adult).

Botulinum toxin type A

9 marketed 7 in Phase 3 2 in Phase 2

This page covers all Botulinum toxin type A drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting SNAP-25 (synaptosome-associated protein of 25 kDa), SNARE complex (synaptobrevin/VAMP), SNARE complex (acetylcholine release machinery at neuromuscular junction).

Targets

SNAP-25 (synaptosome-associated protein of 25 kDa) · SNARE complex (synaptobrevin/VAMP) · SNARE complex (acetylcholine release machinery at neuromuscular junction) · SNARE complex (acetylcholine release machinery) · SNARE complex (synaptosome-associated protein) · SNARE complex (synaptosomal-associated protein) · SNARE proteins (specifically SNAP-25)

Marketed (9)

Botox Cosmetic™ · Carruthers Dermatology Centre · Dermatology / Aesthetics
Botox Cosmetic blocks acetylcholine release at the neuromuscular junction, paralyzing facial muscles and reducing the appearance of wrinkles.
incabotulinumtoxinA · Multiple Sclerosis Center of Northeastern New York · Neurology
IncabotulinumtoxinA is a botulinum toxin type A that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.
Xeomin® · ATGC Co., Ltd. · Neurology / Aesthetics
Xeomin is a botulinum toxin type A that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.
NT 201 · Merz Aesthetics GmbH · Aesthetics/Dermatology
NT 201 is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to temporarily paralyze muscles.
Azzalure or Dysport · Galderma R&D · Dermatology / Aesthetics
Azzalure is a botulinum toxin type A that blocks acetylcholine release at the neuromuscular junction, paralyzing facial muscles and reducing wrinkles.
NAFT500 (adult) · Merz North America, Inc. · Aesthetics / Dermatology
NAFT500 is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions.
NAFT600 (adult) · Merz North America, Inc. · Aesthetics; Neurology
NAFT600 is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions.
Botox 100 UNT Injection · Brigitte Schürch · Neurology, Dermatology, Aesthetics
Botox blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.
PrabotulinumtoxinA-Xvfs · Lupo Center for Aesthetic and General Dermatology · Dermatology / Aesthetics
PrabotulinumtoxinA-Xvfs is a botulinum toxin type A that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.

Phase 3 pipeline (7)

Dysport (R) · Department of Medical Services Ministry of Public Health of Thailand · Neurology, Aesthetics, Movement Disorders
Dysport is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.
Hutox Inj · Huons Co., Ltd. · Aesthetics, Neurology
Hutox is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions.
Dysport Injectable Product · Western University, Canada · Neurology, Dermatology, Aesthetics
Dysport is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.
Neuronox(R) · Department of Medical Services Ministry of Public Health of Thailand · Neurology, Dermatology, Aesthetics
Neuronox is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions.
Placebo / Xeomin · Innovaderm Research Inc. · Neurology / Aesthetics
Xeomin is a botulinum toxin type A that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.
BOTOX®, Allergan · Assistance Publique - Hôpitaux de Paris · Neurology, Dermatology, Ophthalmology
BOTOX blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary paralysis of muscles.
Botulinum Toxin: Xeomin · University Hospital, Clermont-Ferrand · Neurology, Aesthetics
Xeomin is a botulinum toxin type A that blocks acetylcholine release at the neuromuscular junction, causing temporary muscle paralysis.

Phase 2 pipeline (2)

Hyper-Diluted Botox · Steve Yoelin M.D. Medical Associates, Inc. · Aesthetics / Neurology
Hyper-diluted botulinum toxin blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions, potentially at lower concentrations than standard Botox formulations.
DAXI for injection 250 U · Revance Therapeutics, Inc. · Aesthetics / Neurology
DAXI is a botulinum toxin type A formulation that blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions.