What are Bile Acid Sequestrant drugs?

Bile Acid Sequestrant drugs are pharmacologic agents that share a common mechanism (typically targeting Bile acids). 5 are currently marketed, with 4 more in clinical development.

What are the marketed Bile Acid Sequestrant drugs?

Marketed Bile Acid Sequestrant drugs include Welchol, "cholestagel®" (Colesevelam), Colestid, Cholestyramine Powder, colesevelam HCl.

Bile Acid Sequestrant

5 marketed 1 in Phase 3 3 in Phase 2

This page covers all Bile Acid Sequestrant drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Bile acids, Apical sodium-dependent bile acid transporter (ASBT), Bile acids (non-selective binding).

Targets

Bile acids · Apical sodium-dependent bile acid transporter (ASBT) · Bile acids (non-selective binding) · Bile acids / FXR / TGR5

Marketed (5)

Welchol · Cosette · Metabolic
Welchol works by binding to bile acids in the gut, reducing their reabsorption and increasing their excretion, which in turn lowers cholesterol levels and improves blood sugar control.
"cholestagel®" (Colesevelam) · University Hospital, Gentofte, Copenhagen · Cardiovascular
Colesevelam is a bile acid sequestrant that binds bile acids in the intestine, preventing their reabsorption and increasing their fecal excretion.
Colestid · Pfizer · Metabolic
Cholestyramine Powder · Centre Hospitalier Universitaire de Nice · Cardiovascular
Cholestyramine is an anion exchange resin that binds bile acids in the intestine, preventing their reabsorption and increasing fecal excretion.
colesevelam HCl · HealthPartners Institute · Cardiovascular; Endocrinology
Colesevelam is a bile acid sequestrant that binds bile acids in the intestine, preventing their reabsorption and increasing their fecal excretion.

Phase 3 pipeline (1)

Coolprep powder · Taejoon Pharmaceutical Co., Ltd. · Cardiovascular
Coolprep powder is a medication used to treat hypercholesterolemia by inhibiting the absorption of dietary cholesterol.

Phase 2 pipeline (3)

Gutron® treatment · Hospices Civils de Lyon · Cardiovascular
Gutron treatment works by inhibiting the reabsorption of bile acids in the ileum.
Colesevelam Cholestagel · Genzyme, a Sanofi Company · Cardiovascular, Endocrinology
Colesevelam is a bile acid sequestrant that binds bile acids in the intestine to prevent their reabsorption, thereby lowering LDL cholesterol and improving glycemic control.
A3309 · Albireo · Gastroenterology / Metabolic disease
A3309 is a bile acid sequestrant that binds bile acids in the intestine to increase their fecal excretion and modulate metabolic pathways.