Ammonia-lowering agent

This page covers all Ammonia-lowering agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Urea cycle enzymes (ornithine transcarbamylase, carbamoyl phosphate synthetase); glutamine synthetase.

Targets

Urea cycle enzymes (ornithine transcarbamylase, carbamoyl phosphate synthetase); glutamine synthetase

Marketed (2)

• Ornithine aspartate granule · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Hepatology / Gastroenterology
  Ornithine aspartate reduces ammonia levels by promoting its incorporation into urea and glutamine synthesis, thereby improving hepatic encephalopathy symptoms.
• L-ornithine L-aspartate · Medical University of Graz · Hepatology / Gastroenterology
  L-ornithine L-aspartate enhances ammonia detoxification by promoting urea cycle function and glutamine synthesis in hepatic encephalopathy.