What are Amino acid supplement drugs?

Amino acid supplement drugs are pharmacologic agents that share a common mechanism (typically targeting Nitric oxide synthase substrate). 8 are currently marketed, with 3 more in clinical development.

What are the marketed Amino acid supplement drugs?

Marketed Amino acid supplement drugs include L-alanine, L-Serine, L-Arginine, L-Tryptophan, L-lysine, L-Tyrosine.

Amino acid supplement

8 marketed 3 in Phase 3

This page covers all Amino acid supplement drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Nitric oxide synthase substrate, Nitric oxide synthase (substrate), Serotonin synthesis pathway (tryptophan hydroxylase substrate).

Targets

Nitric oxide synthase substrate · Nitric oxide synthase (substrate) · Serotonin synthesis pathway (tryptophan hydroxylase substrate)

Marketed (8)

L-alanine · Keith D Lindor, M.D. · Nutrition / Metabolic support
L-alanine is a non-essential amino acid that serves as a substrate for protein synthesis and gluconeogenesis, supporting cellular metabolism and energy production.
L-Serine · Elijah W. Stommel · Neurology
L-Serine is a non-essential amino acid that serves as a precursor for neurotransmitter and phospholipid synthesis, supporting neurological function and cell membrane integrity.
L-Arginine · The University of Texas at Arlington · Cardiovascular, Immunology, Wound healing
L-Arginine is a semi-essential amino acid that serves as a substrate for nitric oxide synthase, increasing nitric oxide production to improve vascular function and blood flow.
L-Tryptophan · McMaster University · Psychiatry/Neurology
L-Tryptophan is an essential amino acid that serves as a precursor for serotonin and melatonin synthesis, supporting neurotransmitter production and mood regulation.
L-lysine · University of Zurich · Infectious disease / Immune support
L-lysine is an essential amino acid that serves as a protein building block and may have antiviral properties, particularly against herpes simplex virus.
L-Tyrosine · Hadassah Medical Organization · Neurology, Cognitive Enhancement, Nutritional Supplement
L-Tyrosine is a non-essential amino acid that serves as a precursor for the synthesis of catecholamine neurotransmitters (dopamine, norepinephrine, and epinephrine) and thyroid hormones.
L-arginine (L-arginine Veyron) · University Hospital, Strasbourg, France · Cardiovascular
L-arginine is a semi-essential amino acid that serves as a substrate for nitric oxide synthase, increasing nitric oxide production to improve vascular function and blood flow.
L-Histidine · University of Miami · Nutritional/Metabolic
L-Histidine is an essential amino acid that serves as a precursor for histamine and other bioactive compounds involved in immune regulation, gastric acid secretion, and vasodilation.

Phase 3 pipeline (3)

L-tryptophan supplementation · University of Colorado, Denver · Psychiatry/Neurology
L-tryptophan supplementation increases the availability of tryptophan, an essential amino acid that serves as a precursor for serotonin and other neurotransmitters.
Oral L-ornithine aspartate administration · Ukrainian Medical Stomatological Academy · Gastroenterology
Oral L-ornithine aspartate administration increases ornithine levels in the body.
glutamine alone · Air Force Military Medical University, China · Critical Care / Sepsis / Intensive Care Medicine
Glutamine is a conditionally essential amino acid that serves as a primary fuel source for rapidly dividing cells and supports immune function and gut barrier integrity.