What are Alpha-adrenergic antagonist drugs?

Alpha-adrenergic antagonist drugs are pharmacologic agents that share a common mechanism (typically targeting Alpha-1 adrenergic receptor, Alpha-2 adrenergic receptor). 0 are currently marketed, with 3 more in clinical development.

Alpha-adrenergic antagonist

0 marketed 3 in Phase 3

This page covers all Alpha-adrenergic antagonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Alpha-1 adrenergic receptor, Alpha-2 adrenergic receptor, Alpha-1 and alpha-2 adrenergic receptors.

Targets

Alpha-1 adrenergic receptor, Alpha-2 adrenergic receptor · Alpha-1 and alpha-2 adrenergic receptors

Phase 3 pipeline (3)

Phentolamine Opthalmic Solution 0.75% · Ocuphire Pharma, Inc. · Ophthalmology
Phentolamine is an alpha-adrenergic receptor antagonist that blocks norepinephrine signaling in the eye to reduce pupil dilation and improve aqueous humor outflow.
Phentolamine Ophthalmic Solution 0.75% · Ocuphire Pharma, Inc. · Ophthalmology
Phentolamine is an alpha-adrenergic antagonist that blocks norepinephrine signaling in the eye to reduce pupil dilation and improve visual function in patients with presbyopia.
OraVerse Injectable Product · sara nabil · Dental/Local Anesthesia
OraVerse is a phentolamine mesylate injectable that reverses the effects of local anesthetic vasoconstrictors by blocking alpha-adrenergic receptors.