ACE inhibitor plus thiazide diuretic combination

This page covers all ACE inhibitor plus thiazide diuretic combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Angiotensin-converting enzyme (ACE); sodium-chloride cotransporter in the distal convoluted tubule, Angiotensin-converting enzyme (ACE); sodium-chloride cotransporter.

Targets

Angiotensin-converting enzyme (ACE); sodium-chloride cotransporter in the distal convoluted tubule · Angiotensin-converting enzyme (ACE); sodium-chloride cotransporter

Marketed (1)

• Perindopril plus Hydrochlorothiazide · University of Abuja · Cardiovascular
  Perindopril inhibits angiotensin-converting enzyme (ACE) to reduce vasoconstriction and aldosterone secretion, while hydrochlorothiazide promotes sodium and water excretion to lower blood volume, together reducing blood pressure.

Phase 3 pipeline (1)

• Benazepril plus hydrochlorothiazide · Novartis · Cardiovascular
  Benazepril inhibits angiotensin-converting enzyme (ACE) to reduce blood pressure, while hydrochlorothiazide acts as a thiazide diuretic to promote sodium and water excretion.