Last reviewed 2026-04-22 · How we verify

Benazepril plus hydrochlorothiazide

Benazepril inhibits angiotensin-converting enzyme (ACE) to reduce blood pressure, while hydrochlorothiazide acts as a thiazide diuretic to promote sodium and water excretion.

Benazepril inhibits angiotensin-converting enzyme (ACE) to reduce blood pressure, while hydrochlorothiazide acts as a thiazide diuretic to promote sodium and water excretion. Used for Hypertension.

At a glance

Mechanism of action

Benazepril blocks ACE, preventing conversion of angiotensin I to angiotensin II, thereby reducing vasoconstriction and aldosterone secretion. Hydrochlorothiazide increases urinary sodium and water excretion, reducing blood volume and peripheral vascular resistance. The combination provides synergistic antihypertensive effects.

Approved indications

• Hypertension

Common side effects

• Cough
• Dizziness
• Fatigue
• Hyperuricemia
• Hypokalemia
• Headache
• Angioedema

Key clinical trials

• Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension (PHASE3)
• ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
• Coronavirus (COVID-19) ACEi/ARB Investigation (PHASE4)
• Action to Control Cardiovascular Risk in Diabetes (ACCORD) (PHASE3)
• Treatment of High Blood Pressure Using Olmesartan With Hydrochlorothiazide Compared to an ACE Inhibitor With a Calcium Channel Blocker (PHASE4)
• ADDM Study - Amtrel and Co-Diovan in Type 2 Diabetes Mellitus Hypertension Patients With Microalbuminuria (PHASE4)
• Combination of Benazepril Plus Hydrochlorothiazide in Chinese Patients With Mild to Moderate Essential Hypertension (PHASE3)

Primary sources

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