Who are Vitamin K antagonists (VKA)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): PHYTONADIONE, generic warfarin #2, Warfarin duration, Warfarin (Coumadin), Warfarin or coumadin, standard intensity warfarin.

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Last reviewed 2026-05-16 · How we verify

Vitamin K antagonists (VKA) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Vitamin K antagonists (VKA) (Vitamin K antagonists (VKA)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Vitamin K antagonist. Area: Cardiovascular.

phase 3 Vitamin K antagonist VKORC1 Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

Vitamin K antagonists (VKA) (Vitamin K antagonists (VKA)) — Population Health Research Institute. Vitamin K antagonists inhibit the vitamin K-dependent gamma-carboxylation of clotting factors, leading to anticoagulation.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Vitamin K antagonists (VKA) TARGET	Vitamin K antagonists (VKA)	Population Health Research Institute	phase 3	Vitamin K antagonist	VKORC1
PHYTONADIONE	PHYTONADIONE		marketed	Vitamin K [EPC]	Vitamin K epoxide reductase complex subunit 1 (VKORC1)	1982-01-01
generic warfarin #2	generic warfarin #2	Federal University of São Paulo	marketed	Vitamin K antagonist (coumarin anticoagulant)	Vitamin K epoxide reductase complex 1 (VKORC1)
Warfarin duration	Warfarin duration	British Thoracic Society	marketed	Vitamin K antagonist (anticoagulant)	Vitamin K epoxide reductase complex 1 (VKORC1)
Warfarin (Coumadin)	Warfarin (Coumadin)	University of Michigan	marketed	Vitamin K antagonist (oral anticoagulant)	Vitamin K epoxide reductase (VKORC1)
Warfarin or coumadin	Warfarin or coumadin	Ottawa Heart Institute Research Corporation	marketed	Vitamin K antagonist (oral anticoagulant)	Vitamin K epoxide reductase complex 1 (VKORC1)
standard intensity warfarin	standard intensity warfarin	The First Affiliated Hospital with Nanjing Medical University	marketed	Vitamin K antagonist (VKA)	Vitamin K epoxide reductase complex 1 (VKORC1)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Vitamin K antagonist class)

Joon Bum Kim · 1 drug in this class
Population Health Research Institute · 1 drug in this class
US Department of Veterans Affairs · 1 drug in this class
University Hospital, Bonn · 1 drug in this class
University Hospital, Limoges · 1 drug in this class
Yunhe Pharmaceutical (Tianjin) Co., Ltd · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Vitamin K antagonists (VKA) — Competitive Intelligence Brief. https://druglandscape.com/ci/vitamin-k-antagonists-vka. Accessed 2026-05-16.

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