Who are Trimethoprim's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Gentamicin, Wellcovorin, Klaron, LMWH+Folic acid, Artesunate + Sulfadoxine-Pyrimethamine, Atovaquone / Proguanil.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

Trimethoprim — Competitive Intelligence Brief

Trimethoprim (TRIMETHOPRIM) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Sulfonamide Antimicrobial [EPC]. Area: Immunology.

marketed Sulfonamide Antimicrobial [EPC] Dihydrofolate reductase Immunology Small molecule Live · refreshed every 30 min

Target snapshot

Trimethoprim (TRIMETHOPRIM) — Dr Reddys Labs Sa.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Trimethoprim TARGET	TRIMETHOPRIM	Dr Reddys Labs Sa	marketed	Sulfonamide Antimicrobial [EPC]	Dihydrofolate reductase	1973-01-01
Gentamicin	Gentamicin Sulfate	Merck & Co.	marketed	gentamicin	Dihydrofolate reductase	1970-01-01
Wellcovorin	leucovorin	Pfizer Japan Inc	marketed	Folate Analog	Dihydrofolate reductase	1952-01-01
Klaron	SULFACETAMIDE	Merck & Co.	marketed	Sulfonamide Antibacterial	Dihydrofolate reductase	1945-01-01
LMWH+Folic acid	LMWH+Folic acid	Omar Mamdouh Shaaban	marketed	Anticoagulant combination with vitamin supplement	Factor Xa, Thrombin (LMWH component); Dihydrofolate reductase (folic acid component)
Artesunate + Sulfadoxine-Pyrimethamine	Artesunate + Sulfadoxine-Pyrimethamine	Sanofi	marketed	Antimalarial combination	Plasmodium falciparum (multiple targets: artemisinin-induced oxidative stress; dihydrofolate reductase; dihydropteroate synthase)
Atovaquone / Proguanil	Atovaquone / Proguanil	Radboud University Medical Center	marketed	Antimalarial combination	Mitochondrial electron transport chain (atovaquone); dihydrofolate reductase (proguanil)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Sulfonamide Antimicrobial [EPC] class)

Dr Reddys Labs Sa · 1 drug in this class
Pfizer · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Trimethoprim — Competitive Intelligence Brief. https://druglandscape.com/ci/trimethoprim. Accessed 2026-05-14.

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