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tegafur-uracil — Competitive Intelligence Brief
marketed
Antimetabolite; 5-fluorouracil prodrug
Thymidylate synthase
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
tegafur-uracil (tegafur-uracil) — Yokohama City University. Tegafur-uracil is a combination prodrug that is converted to fluorouracil in the body to inhibit thymidylate synthase and disrupt DNA synthesis in cancer cells.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| tegafur-uracil TARGET | tegafur-uracil | Yokohama City University | marketed | Antimetabolite; 5-fluorouracil prodrug | Thymidylate synthase | |
| Xeloda | capecitabine | Cheplapharm | marketed | Nucleoside Metabolic Inhibitor [EPC] | Thymidylate synthase | 1998-01-01 |
| Fudr | FLOXURIDINE | marketed | Antimetabolite [EPC] | Thymidylate synthase | 1970-01-01 | |
| Folic Acid | FOLIC ACID | Pfizer | marketed | Vitamin C [EPC] | Thymidylate synthase | 1946-01-01 |
| Fluorouracil Injection | Fluorouracil Injection | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | marketed | Antimetabolite | Thymidylate synthase | |
| 5-Fluorouracile | 5-Fluorouracile | Groupe Oncologie Radiotherapie Tete et Cou | marketed | Antimetabolite; pyrimidine analog | Thymidylate synthase; RNA and DNA incorporation | |
| 5-Fluouracil | 5-Fluouracil | Hoffmann-La Roche | marketed | Antimetabolite | Thymidylate synthase; RNA and DNA incorporation |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Antimetabolite; 5-fluorouracil prodrug class)
- Liaoning Cancer Hospital & Institute · 1 drug in this class
- Yokohama City University · 1 drug in this class
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Cite this brief
Drug Landscape (2026). tegafur-uracil — Competitive Intelligence Brief. https://druglandscape.com/ci/tegafur-uracil. Accessed 2026-06-10.
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