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Sulfamethoxazole-Trimethoprim — Competitive Intelligence Brief
marketed
Sulfonamide-dihydrofolate reductase inhibitor combination
Dihydropteroate synthase; Dihydrofolate reductase
Infectious Disease
Small molecule
Live · refreshed every 30 min
Target snapshot
Sulfamethoxazole-Trimethoprim (Sulfamethoxazole-Trimethoprim) — National Institute of Allergy and Infectious Diseases (NIAID). Sulfamethoxazole-trimethoprim is a fixed-dose combination antibiotic that inhibits bacterial folate synthesis by blocking dihydrofolate reductase and dihydropteroate synthase.
Comparator set (2 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Sulfamethoxazole-Trimethoprim TARGET | Sulfamethoxazole-Trimethoprim | National Institute of Allergy and Infectious Diseases (NIAID) | marketed | Sulfonamide-dihydrofolate reductase inhibitor combination | Dihydropteroate synthase; Dihydrofolate reductase | |
| Sulfamethoxazole Trimethoprim Combination | Sulfamethoxazole Trimethoprim Combination | Baylor Research Institute | marketed | Sulfonamide-dihydrofolate reductase inhibitor combination | Dihydropteroate synthase; Dihydrofolate reductase | |
| Sulfadoxine-pyrimethamine used for IPTi | Sulfadoxine-pyrimethamine used for IPTi | Swiss Tropical & Public Health Institute | phase 3 | Antifolate antimalarial combination | Dihydropteroate synthase; Dihydrofolate reductase |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Sulfonamide-dihydrofolate reductase inhibitor combination class)
- Baylor Research Institute · 1 drug in this class
- National Institute of Allergy and Infectious Diseases (NIAID) · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Sulfamethoxazole-Trimethoprim — Competitive Intelligence Brief. https://druglandscape.com/ci/sulfamethoxazole-trimethoprim. Accessed 2026-05-16.
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