Who are rhDNAse's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Fabrazyme (agalsidase beta), Dornase alfa (Pulmozyme), DNase, recAP, Pulmozyme®, Dornase Alfa Inhalation Solution.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

rhDNAse — Competitive Intelligence Brief

rhDNAse (rhDNAse) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Recombinant enzyme. Area: Respiratory / Pulmonary.

marketed Recombinant enzyme Extracellular DNA (deoxyribonucleic acid) Respiratory / Pulmonary Small molecule Live · refreshed every 30 min

Target snapshot

rhDNAse (rhDNAse) — The Hospital for Sick Children. rhDNAse is a recombinant human deoxyribonuclease that breaks down extracellular DNA in airway secretions to reduce mucus viscosity.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
rhDNAse TARGET	rhDNAse	The Hospital for Sick Children	marketed	Recombinant enzyme	Extracellular DNA (deoxyribonucleic acid)
Fabrazyme (agalsidase beta)	Fabrazyme (agalsidase beta)	Genzyme, a Sanofi Company	marketed	Enzyme replacement therapy (ERT); recombinant enzyme	α-galactosidase A (GLA gene product); substrate: globotriaosylceramide (GL-3)
Dornase alfa (Pulmozyme)	Dornase alfa (Pulmozyme)	University of Jena	marketed	Recombinant enzyme	Extracellular DNA (deoxyribonucleic acid)
DNase	DNase	The Hospital for Sick Children	marketed	Recombinant enzyme	Deoxyribonucleic acid (DNA)
recAP	recAP	AM-Pharma	marketed	Recombinant enzyme	Lipopolysaccharide (LPS) and pathogen-associated molecular patterns (PAMPs)
Pulmozyme®	Pulmozyme®	AO GENERIUM	marketed	Recombinant enzyme	Extracellular DNA
Dornase Alfa Inhalation Solution	Dornase Alfa Inhalation Solution	University of Missouri-Columbia	phase 3	Recombinant enzyme	Extracellular DNA (deoxyribonucleic acid)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Recombinant enzyme class)

The Hospital for Sick Children · 2 drugs in this class
AO GENERIUM · 1 drug in this class
Fondation Ophtalmologique Adolphe de Rothschild · 1 drug in this class
Protalix · 1 drug in this class
University Hospital, Strasbourg, France · 1 drug in this class
University of Jena · 1 drug in this class
AM-Pharma · 1 drug in this class
University of Missouri-Columbia · 1 drug in this class

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Cite this brief

Drug Landscape (2026). rhDNAse — Competitive Intelligence Brief. https://druglandscape.com/ci/rhdnase. Accessed 2026-05-13.

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