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Rh-endostatin — Competitive Intelligence Brief
phase 3
Angiogenesis inhibitor
VEGF signaling pathway; endothelial cells
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Rh-endostatin (Rh-endostatin) — Guangzhou Institute of Respiratory Disease. Rh-endostatin inhibits angiogenesis by blocking new blood vessel formation, thereby starving tumors of their blood supply.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Rh-endostatin TARGET | Rh-endostatin | Guangzhou Institute of Respiratory Disease | phase 3 | Angiogenesis inhibitor | VEGF signaling pathway; endothelial cells | |
| Endostar continuous intravenous infusion | Endostar continuous intravenous infusion | Jiangsu Simcere Pharmaceutical Co., Ltd. | phase 3 | Angiogenesis inhibitor | VEGF signaling pathway; endothelial cells | |
| Endostar routine intravenous infusion | Endostar routine intravenous infusion | Jiangsu Simcere Pharmaceutical Co., Ltd. | phase 3 | Angiogenesis inhibitor | VEGF signaling pathway; endothelial cells | |
| recombinant human endostatin | recombinant human endostatin | Peking University Cancer Hospital & Institute | marketed | Angiogenesis inhibitor | Endothelial cells (multiple pathways including integrin and VEGF-related mechanisms) | |
| endostar+chemoradiotherapy | endostar+chemoradiotherapy | Second Affiliated Hospital of Xi'an Jiaotong University | marketed | Angiogenesis inhibitor | Endothelial cells; inhibits multiple angiogenic pathways | |
| Ramucirumab+ paclitaxel | Ramucirumab+ paclitaxel | AstraZeneca | phase 3 | Angiogenesis inhibitor, Microtubule inhibitor | VEGFR2 | |
| bevacizumab plus chemotherapy | bevacizumab plus chemotherapy | Liaoning Cancer Hospital & Institute | phase 3 | Angiogenesis inhibitor | VEGF-A |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Angiogenesis inhibitor class)
- Jiangsu Simcere Pharmaceutical Co., Ltd. · 3 drugs in this class
- Eli Lilly and Company · 1 drug in this class
- Guangzhou Institute of Respiratory Disease · 1 drug in this class
- Hoffmann-La Roche · 1 drug in this class
- Liaoning Cancer Hospital & Institute · 1 drug in this class
- PPD Development, LP · 1 drug in this class
- Peking University Cancer Hospital & Institute · 1 drug in this class
- Sanofi · 1 drug in this class
- ARCAGY/ GINECO GROUP · 1 drug in this class
- Second Affiliated Hospital of Xi'an Jiaotong University · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Rh-endostatin — Competitive Intelligence Brief. https://druglandscape.com/ci/rh-endostatin. Accessed 2026-06-10.
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