Who are Oxymetazoline HCL Cream 1.0%'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Comparator: carvedilol, Doxazosin mysylate GITS, Placebo to Prazosin, placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan, Norepinephrine (Levophed), Cyclopentolate+tropicamide+phenylephrine.

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Last reviewed 2026-05-16 · How we verify

Oxymetazoline HCL Cream 1.0% — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Oxymetazoline HCL Cream 1.0% (Oxymetazoline HCL Cream 1.0%) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Alpha-1 adrenergic agonist. Area: Dermatology.

marketed Alpha-1 adrenergic agonist Alpha-1 adrenergic receptor Dermatology Small molecule Live · refreshed every 30 min

Target snapshot

Oxymetazoline HCL Cream 1.0% (Oxymetazoline HCL Cream 1.0%) — Allergan. Oxymetazoline is an alpha-1 adrenergic agonist that causes vasoconstriction of blood vessels in the skin, reducing redness and flushing.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Oxymetazoline HCL Cream 1.0% TARGET	Oxymetazoline HCL Cream 1.0%	Allergan	marketed	Alpha-1 adrenergic agonist	Alpha-1 adrenergic receptor
Comparator: carvedilol	Comparator: carvedilol	Organon and Co	marketed	Beta-blocker with alpha-1 antagonist activity	Beta-1 adrenergic receptor, Beta-2 adrenergic receptor, Alpha-1 adrenergic receptor
Doxazosin mysylate GITS	Doxazosin mysylate GITS	Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	marketed	Alpha-1 adrenergic receptor antagonist	Alpha-1 adrenergic receptor
Placebo to Prazosin	Placebo to Prazosin	Brian J Lipworth	marketed	Alpha-1 adrenergic receptor antagonist	Alpha-1 adrenergic receptor
placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan	placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan	Montefiore Medical Center	marketed	Combination cold and cough remedy	H1 receptor (diphenhydramine); alpha-1 adrenergic receptor (phenylephrine); sigma-1 receptor and NMDA receptor (dextromethorphan)
Norepinephrine (Levophed)	Norepinephrine (Levophed)	University of Louisville	marketed	Catecholamine; sympathomimetic amine	Alpha-1 adrenergic receptor; alpha-2 adrenergic receptor; beta-1 adrenergic receptor
Cyclopentolate+tropicamide+phenylephrine	Cyclopentolate+tropicamide+phenylephrine	Pontificia Universidad Catolica de Chile	marketed	Anticholinergic + sympathomimetic combination	Muscarinic acetylcholine receptors (M1-M5); alpha-1 adrenergic receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Alpha-1 adrenergic agonist class)

Allergan · 2 drugs in this class
EMS · 1 drug in this class
Institute of Liver and Biliary Sciences, India · 1 drug in this class
Medical University of Graz · 1 drug in this class
Rawalpindi Medical College · 1 drug in this class
Tehran Heart Center · 1 drug in this class
Actavis Inc. · 1 drug in this class
University Tunis El Manar · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Oxymetazoline HCL Cream 1.0% — Competitive Intelligence Brief. https://druglandscape.com/ci/oxymetazoline-hcl-cream-1-0. Accessed 2026-05-16.

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