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Ondansetron oral tablets — Competitive Intelligence Brief
phase 3
Serotonin 5-HT3 receptor antagonist
5-HT3 receptor
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Ondansetron oral tablets (Ondansetron oral tablets) — GlaxoSmithKline. Ondansetron works by blocking serotonin receptors in the body, which helps to reduce nausea and vomiting.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Ondansetron oral tablets TARGET | Ondansetron oral tablets | GlaxoSmithKline | phase 3 | Serotonin 5-HT3 receptor antagonist | 5-HT3 receptor | |
| Trintellix | vortioxetine | Takeda | marketed | Serotonin modulator and stimulator (SMS); SSRI-like agent | Serotonin transporter (SERT); 5-HT3 receptor; 5-HT1A receptor | 2013-01-01 |
| ramosetron, ondansetron, dexamethasone | ramosetron, ondansetron, dexamethasone | Government Medical College, Haldwani | marketed | 5-HT3 receptor antagonist + corticosteroid combination | 5-HT3 receptor (ramosetron, ondansetron); glucocorticoid receptor (dexamethasone) | |
| Ramosetron, Aprepitant, Dexamethasone | Ramosetron, Aprepitant, Dexamethasone | Hallym University Medical Center | marketed | 5-HT3 antagonist / NK1 antagonist / corticosteroid combination | 5-HT3 receptor, NK1 receptor, glucocorticoid receptor | |
| Metoclopramide, Granisetron, or Ondansetron | Metoclopramide, Granisetron, or Ondansetron | Sanofi | marketed | Antiemetic agents (dopamine antagonist, 5-HT3 receptor antagonists) | Dopamine receptors (metoclopramide); 5-HT3 receptors (granisetron, ondansetron) | |
| Dexamethasone, Ondansetron, Aprepitant | Dexamethasone, Ondansetron, Aprepitant | Ottawa Hospital Research Institute | marketed | Antiemetic combination (corticosteroid + 5-HT3 antagonist + NK1 antagonist) | Glucocorticoid receptor, 5-HT3 receptor, NK1 receptor | |
| ondansetron (Zofran) | ondansetron (Zofran) | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | marketed | 5-HT3 receptor antagonist | 5-HT3 receptor |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Serotonin 5-HT3 receptor antagonist class)
- CCTU · 1 drug in this class
- GlaxoSmithKline · 1 drug in this class
- RedHill Biopharma Limited · 1 drug in this class
- The First Affiliated Hospital of Xinxiang Medical College · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Ondansetron oral tablets — Competitive Intelligence Brief. https://druglandscape.com/ci/ondansetron-oral-tablets. Accessed 2026-05-17.
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