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Ondansetron oral tablets — Competitive Intelligence Brief

Ondansetron oral tablets (Ondansetron oral tablets) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Serotonin 5-HT3 receptor antagonist. Area: Oncology.

phase 3 Serotonin 5-HT3 receptor antagonist 5-HT3 receptor Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Ondansetron oral tablets (Ondansetron oral tablets) — GlaxoSmithKline. Ondansetron works by blocking serotonin receptors in the body, which helps to reduce nausea and vomiting.

Comparator set (6 drugs)

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DrugGenericSponsorPhaseClassTargetApproval / PDUFA
Ondansetron oral tablets TARGET Ondansetron oral tablets GlaxoSmithKline phase 3 Serotonin 5-HT3 receptor antagonist 5-HT3 receptor
Trintellix vortioxetine Takeda marketed Serotonin modulator and stimulator (SMS); SSRI-like agent Serotonin transporter (SERT); 5-HT3 receptor; 5-HT1A receptor 2013-01-01
ramosetron, ondansetron, dexamethasone ramosetron, ondansetron, dexamethasone Government Medical College, Haldwani marketed 5-HT3 receptor antagonist + corticosteroid combination 5-HT3 receptor (ramosetron, ondansetron); glucocorticoid receptor (dexamethasone)
Ramosetron, Aprepitant, Dexamethasone Ramosetron, Aprepitant, Dexamethasone Hallym University Medical Center marketed 5-HT3 antagonist / NK1 antagonist / corticosteroid combination 5-HT3 receptor, NK1 receptor, glucocorticoid receptor
Metoclopramide, Granisetron, or Ondansetron Metoclopramide, Granisetron, or Ondansetron Sanofi marketed Antiemetic agents (dopamine antagonist, 5-HT3 receptor antagonists) Dopamine receptors (metoclopramide); 5-HT3 receptors (granisetron, ondansetron)
Dexamethasone, Ondansetron, Aprepitant Dexamethasone, Ondansetron, Aprepitant Ottawa Hospital Research Institute marketed Antiemetic combination (corticosteroid + 5-HT3 antagonist + NK1 antagonist) Glucocorticoid receptor, 5-HT3 receptor, NK1 receptor
ondansetron (Zofran) ondansetron (Zofran) National Institute on Alcohol Abuse and Alcoholism (NIAAA) marketed 5-HT3 receptor antagonist 5-HT3 receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Serotonin 5-HT3 receptor antagonist class)

  1. CCTU · 1 drug in this class
  2. GlaxoSmithKline · 1 drug in this class
  3. RedHill Biopharma Limited · 1 drug in this class
  4. The First Affiliated Hospital of Xinxiang Medical College · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Ondansetron oral tablets — Competitive Intelligence Brief. https://druglandscape.com/ci/ondansetron-oral-tablets. Accessed 2026-05-17.

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