Who are Ondansetron (ODT)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Trintellix, Palonosetron (Group P), Palonosetron only, Treatment 2 Ondansetron, Dexamethasone, Ondansetron, Aprepitant, Mirtazapine/SNRIs.

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Last reviewed 2026-06-10 · How we verify

Ondansetron (ODT) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ondansetron (ODT) (Ondansetron (ODT)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: 5-HT3 receptor antagonist. Area: Oncology, Gastroenterology.

marketed 5-HT3 receptor antagonist 5-HT3 receptor Oncology, Gastroenterology Small molecule Live · refreshed every 30 min

Target snapshot

Ondansetron (ODT) (Ondansetron (ODT)) — MonoSol Rx. Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Ondansetron (ODT) TARGET	Ondansetron (ODT)	MonoSol Rx	marketed	5-HT3 receptor antagonist	5-HT3 receptor
Trintellix	vortioxetine	Takeda	marketed	Serotonin modulator and stimulator (SMS); SSRI-like agent	Serotonin transporter (SERT); 5-HT3 receptor; 5-HT1A receptor	2013-01-01
Palonosetron (Group P)	Palonosetron (Group P)	University of Malaya	marketed	5-HT3 receptor antagonist	5-HT3 receptor
Palonosetron only	Palonosetron only	NYU Langone Health	marketed	5-HT3 receptor antagonist	5-HT3 receptor
Treatment 2 Ondansetron	Treatment 2 Ondansetron	Hamad Medical Corporation	marketed	5-HT3 receptor antagonist	5-HT3 receptor
Dexamethasone, Ondansetron, Aprepitant	Dexamethasone, Ondansetron, Aprepitant	Ottawa Hospital Research Institute	marketed	Antiemetic combination (corticosteroid + 5-HT3 antagonist + NK1 antagonist)	Glucocorticoid receptor, 5-HT3 receptor, NK1 receptor
Mirtazapine/SNRIs	Mirtazapine/SNRIs	Shanghai Mental Health Center	marketed	Tetracyclic antidepressant	Alpha-2 adrenergic receptors, 5-HT2 receptors, 5-HT3 receptors

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (5-HT3 receptor antagonist class)

Helsinn Healthcare SA · 4 drugs in this class
LG Life Sciences · 3 drugs in this class
University of Malaya · 2 drugs in this class
GlaxoSmithKline · 1 drug in this class
Hamad Medical Corporation · 1 drug in this class
Eye & ENT Hospital of Fudan University · 1 drug in this class
Instituto Mexicano del Seguro Social · 1 drug in this class
Chongqing University Cancer Hospital · 1 drug in this class
Merck Sharp & Dohme LLC · 1 drug in this class
MonoSol Rx · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Ondansetron (ODT) — Competitive Intelligence Brief. https://druglandscape.com/ci/ondansetron-odt. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing