Who are Next-line ibrutinib's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): (G) BQ-L14, Placebo matched to fenebrutinib, R-miniCHOP + Acalabrutinib, Ibrutinib combined with As2O3, Orelabrutinib and R-CHOP, PCI-32765 (Ibrutinib).

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Last reviewed 2026-06-10 · How we verify

Next-line ibrutinib — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Next-line ibrutinib (Next-line ibrutinib) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: BTK inhibitor. Area: Oncology.

phase 3 BTK inhibitor BTK (Bruton's tyrosine kinase) Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Next-line ibrutinib (Next-line ibrutinib) — Pharmacyclics LLC.. Ibrutinib is a Bruton's tyrosine kinase (BTK) inhibitor that blocks BTK signaling in B cells and other immune cells, leading to reduced proliferation and survival of malignant B cells.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Next-line ibrutinib TARGET	Next-line ibrutinib	Pharmacyclics LLC.	phase 3	BTK inhibitor	BTK (Bruton's tyrosine kinase)
(G) BQ-L14	(G) BQ-L14	National Taiwan University Hospital	marketed	BTK inhibitor	BTK
Placebo matched to fenebrutinib	Placebo matched to fenebrutinib	Hoffmann-La Roche	phase 3	Placebo (matched to BTK inhibitor)
R-miniCHOP + Acalabrutinib	R-miniCHOP + Acalabrutinib	Universität des Saarlandes	phase 3	Combination therapy: monoclonal antibody + chemotherapy + BTK inhibitor	CD20 (rituximab component); Bruton tyrosine kinase / BTK (acalabrutinib component)
Ibrutinib combined with As2O3	Ibrutinib combined with As2O3	Peking University People's Hospital	phase 3	BTK inhibitor combined with arsenic compound	BTK (Bruton's tyrosine kinase); As2O3 has multiple targets including PML-RARA fusion protein and mitochondrial pathways
Orelabrutinib and R-CHOP	Orelabrutinib and R-CHOP	Beijing InnoCare Pharma Tech Co., Ltd.	phase 3	BTK inhibitor	BTK
PCI-32765 (Ibrutinib)	PCI-32765 (Ibrutinib)	Janssen Research & Development, LLC	phase 3	BTK inhibitor	BTK (Bruton's tyrosine kinase)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (BTK inhibitor class)

Acerta Pharma BV · 4 drugs in this class
AstraZeneca · 4 drugs in this class
AbbVie · 2 drugs in this class
Eli Lilly and Company · 1 drug in this class
Fuji Yakuhin Co., Ltd. · 1 drug in this class
Genzyme, a Sanofi Company · 1 drug in this class
GlaxoSmithKline · 1 drug in this class
Janssen Research & Development, LLC · 1 drug in this class
National Taiwan University Hospital · 1 drug in this class
Pfizer · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Next-line ibrutinib — Competitive Intelligence Brief. https://druglandscape.com/ci/next-line-ibrutinib. Accessed 2026-06-10.

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