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neostigmine/glycopyrolate — Competitive Intelligence Brief

neostigmine/glycopyrolate (neostigmine/glycopyrolate) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Cholinesterase inhibitor with anticholinergic agent. Area: Neurology / Anesthesia.

marketed Cholinesterase inhibitor with anticholinergic agent Acetylcholinesterase (neostigmine); muscarinic acetylcholine receptors (glycopyrolate) Neurology / Anesthesia Small molecule Live · refreshed every 30 min

Target snapshot

neostigmine/glycopyrolate (neostigmine/glycopyrolate) — Henry Ford Health System. Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrolate blocks muscarinic receptors to counteract parasympathomimetic side effects.

Comparator set (6 drugs)

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DrugGenericSponsorPhaseClassTargetApproval / PDUFA
neostigmine/glycopyrolate TARGET neostigmine/glycopyrolate Henry Ford Health System marketed Cholinesterase inhibitor with anticholinergic agent Acetylcholinesterase (neostigmine); muscarinic acetylcholine receptors (glycopyrolate)
Neostigmine and Glycopyrrolate Neostigmine and Glycopyrrolate James J. Peters Veterans Affairs Medical Center marketed Cholinesterase inhibitor with anticholinergic agent Acetylcholinesterase (neostigmine); Muscarinic acetylcholine receptors (glycopyrrolate)
Neostigmine with glycopyrrolate Neostigmine with glycopyrrolate The Cleveland Clinic marketed Acetylcholinesterase inhibitor with anticholinergic agent Acetylcholinesterase; muscarinic acetylcholine receptors
Neostigmine w/ Glycopyrrolate Neostigmine w/ Glycopyrrolate University of Texas Southwestern Medical Center marketed Acetylcholinesterase inhibitor with anticholinergic agent Acetylcholinesterase (neostigmine); muscarinic acetylcholine receptors (glycopyrrolate)
Neostigmine + Glycopyrrolate Neostigmine + Glycopyrrolate Merck Sharp & Dohme LLC marketed Acetylcholinesterase inhibitor with anticholinergic agent Acetylcholinesterase (neostigmine); Muscarinic acetylcholine receptors (glycopyrrolate)
Combination of Neostigmine and Glycopyrrolate Combination of Neostigmine and Glycopyrrolate James J. Peters Veterans Affairs Medical Center phase 3 Cholinesterase inhibitor with anticholinergic agent Acetylcholinesterase (neostigmine); Muscarinic acetylcholine receptors (glycopyrrolate)
neostigmine and glycopyrrolate or atropine neostigmine and glycopyrrolate or atropine Merck Sharp & Dohme LLC phase 3 Cholinesterase inhibitor with anticholinergic agent Acetylcholinesterase (neostigmine); muscarinic acetylcholine receptors (glycopyrrolate/atropine)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Cholinesterase inhibitor with anticholinergic agent class)

  1. James J. Peters Veterans Affairs Medical Center · 2 drugs in this class
  2. Henry Ford Health System · 1 drug in this class
  3. Merck Sharp & Dohme LLC · 1 drug in this class

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Cite this brief

Drug Landscape (2026). neostigmine/glycopyrolate — Competitive Intelligence Brief. https://druglandscape.com/ci/neostigmine-glycopyrolate. Accessed 2026-05-16.

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