Who are Natalizumab (Tysabri)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Vedolizumab IV, BG00002 (natalizumab), natalizumab (NTZ), Vedolizumab SC, Tavilermide ophthalmic solution.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Natalizumab (Tysabri) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Natalizumab (Tysabri) (Natalizumab (Tysabri)) competitive landscape: 5 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Monoclonal antibody; integrin antagonist. Area: Immunology; Neurology; Gastroenterology.

marketed Monoclonal antibody; integrin antagonist α4β1 integrin (VLA-4) Immunology; Neurology; Gastroenterology Small molecule Live · refreshed every 30 min

Target snapshot

Natalizumab (Tysabri) (Natalizumab (Tysabri)) — Cornerstone Health Care, PA. Natalizumab is a monoclonal antibody that blocks the α4β1 integrin on immune cells, preventing them from crossing the blood-brain barrier and entering the central nervous system.

Comparator set (5 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Natalizumab (Tysabri) TARGET	Natalizumab (Tysabri)	Cornerstone Health Care, PA	marketed	Monoclonal antibody; integrin antagonist	α4β1 integrin (VLA-4)
Vedolizumab IV	Vedolizumab IV	Takeda	marketed	Integrin antagonist monoclonal antibody	α4β7 integrin
BG00002 (natalizumab)	BG00002 (natalizumab)	Biogen	marketed	Monoclonal antibody (integrin antagonist)	α4β1 integrin
natalizumab (NTZ)	natalizumab (NTZ)	University Hospital, Clermont-Ferrand	marketed	Monoclonal antibody (integrin antagonist)	α4β1 integrin (VLA-4)
Vedolizumab SC	Vedolizumab SC	Takeda	marketed	Integrin antagonist; monoclonal antibody	α4β7 integrin
Tavilermide ophthalmic solution	Tavilermide ophthalmic solution	Mimetogen Pharmaceuticals USA, Inc.	phase 3	Integrin antagonist	Integrins (α4β1, αLβ2, and other integrin subtypes)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Monoclonal antibody; integrin antagonist class)

Cornerstone Health Care, PA · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Natalizumab (Tysabri) — Competitive Intelligence Brief. https://druglandscape.com/ci/natalizumab-tysabri. Accessed 2026-05-16.

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