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MVA-BN half-dose regimen — Competitive Intelligence Brief
phase 3
Live attenuated viral vaccine
Monkeypox virus antigens (L1, A29, I3, I4, I5 proteins)
Immunology / Infectious Disease
Biologic
Live · refreshed every 30 min
Target snapshot
MVA-BN half-dose regimen (MVA-BN half-dose regimen) — Jean-Pierre Van geertruyden. MVA-BN is a modified vaccinia Ankara-based vaccine expressing monkeypox antigens that primes the immune system to recognize and respond to monkeypox virus infection.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| MVA-BN half-dose regimen TARGET | MVA-BN half-dose regimen | Jean-Pierre Van geertruyden | phase 3 | Live attenuated viral vaccine | Monkeypox virus antigens (L1, A29, I3, I4, I5 proteins) | |
| Smallpox and Mpox Vaccine | Smallpox and Mpox Vaccine | SIGA Technologies | marketed | Live attenuated viral vaccine / Recombinant viral vaccine | ||
| Measles, Mumps, and Rubella Virus Vaccine | Measles, Mumps, and Rubella Virus Vaccine | Sanofi Pasteur, a Sanofi Company | marketed | Live attenuated viral vaccine | ||
| JYNNEOS | JYNNEOS | Womack Army Medical Center | marketed | Live attenuated viral vaccine | Orthopoxvirus antigens (vaccinia virus envelope and core proteins) | |
| M-M-RTM II | M-M-RTM II | Merck Sharp & Dohme LLC | marketed | Live attenuated viral vaccine | ||
| bOPV 1,3 | bOPV 1,3 | Institute of Medical Biology, Chinese Academy of Medical Sciences | marketed | Live attenuated viral vaccine | Poliovirus types 1 and 3 | |
| measles-rubella vaccine | measles-rubella vaccine | Sichuan Center for Disease Control and Prevention | marketed | Live attenuated viral vaccine |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Live attenuated viral vaccine class)
- Jean-Pierre Van geertruyden · 2 drugs in this class
- Sanofi Pasteur, a Sanofi Company · 2 drugs in this class
- Centers for Disease Control and Prevention · 1 drug in this class
- GlaxoSmithKline · 1 drug in this class
- Hospital Clinic of Barcelona · 1 drug in this class
- Institute of Medical Biology, Chinese Academy of Medical Sciences · 1 drug in this class
- Institute of Tropical Medicine, Belgium · 1 drug in this class
- International Vaccine Institute · 1 drug in this class
- Merck Sharp & Dohme LLC · 1 drug in this class
- National Institute of Allergy and Infectious Diseases (NIAID) · 1 drug in this class
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Cite this brief
Drug Landscape (2026). MVA-BN half-dose regimen — Competitive Intelligence Brief. https://druglandscape.com/ci/mva-bn-half-dose-regimen. Accessed 2026-05-16.
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