Who are Motilitone® and Pantoline®'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): DA-9701, Reglan, Motilium, Placebo domperidone, Drug either PPIS or H2RA and prokinetics, Metoclopramide hydrochloride monohydrate.

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Last reviewed 2026-05-16 · How we verify

Motilitone® and Pantoline® — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Motilitone® and Pantoline® (Motilitone® and Pantoline®) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Prokinetic agent. Area: Gastroenterology.

marketed Prokinetic agent Dopamine receptor antagonist; acetylcholinesterase inhibitor Gastroenterology Small molecule Live · refreshed every 30 min

Target snapshot

Motilitone® and Pantoline® (Motilitone® and Pantoline®) — Dong-A ST Co., Ltd.. Motilitone enhances gastric muscle contractions and accelerates gastric emptying by acting as a dopamine antagonist and acetylcholinesterase inhibitor.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Motilitone® and Pantoline® TARGET	Motilitone® and Pantoline®	Dong-A ST Co., Ltd.	marketed	Prokinetic agent	Dopamine receptor antagonist; acetylcholinesterase inhibitor
DA-9701	DA-9701	Seoul National University Hospital	marketed	Prokinetic agent	Dopamine receptor antagonist; acetylcholinesterase inhibitor
Reglan	Metoclopramide Hydrochloride	Hikma	marketed	Prokinetic agent	Acetylcholine receptor sensitization; dopamine antagonism (implied)	1979-01-01
Motilium	domperidone	Johnson & Johnson (Janssen)	marketed	Prokinetic agent / Antiemetic	Aldehyde oxidase, Multidrug and toxin extrusion protein 1, Multidrug and toxin extrusion protein 2	1978-01-01
Placebo domperidone	Placebo domperidone	Seoul National University Hospital	marketed	Dopamine antagonist / Prokinetic agent	Dopamine D2 receptor
Drug either PPIS or H2RA and prokinetics	Drug either PPIS or H2RA and prokinetics	King Saud University	marketed	Combination antacid and prokinetic agent	H+/K+-ATPase (PPIs) or H2 receptor (H2RAs); dopamine antagonist or other prokinetic target
Metoclopramide hydrochloride monohydrate	Metoclopramide hydrochloride monohydrate	CM Chungmu Hospital	marketed	Dopamine antagonist / Antiemetic / Prokinetic agent	Dopamine D2 receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2029-12-22 — Reglan · 11813231 · Formulation · US
2029-12-22 — Reglan · 12194009 · Method of Use · US
2029-12-22 — Reglan · 12194008 · Method of Use · US
2029-12-22 — Reglan · 11020361 · Method of Use · US
2029-12-22 — Reglan · 11628150 · Formulation · US
2030-05-16 — Reglan · 8334281 · Formulation · US
2038-11-17 — Reglan · 12377064 · Method of Use · US

Sponsor landscape (Prokinetic agent class)

Dong-A ST Co., Ltd. · 1 drug in this class
Hikma · 1 drug in this class
Seoul National University Hospital · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Motilitone® and Pantoline® — Competitive Intelligence Brief. https://druglandscape.com/ci/motilitone-and-pantoline. Accessed 2026-05-16.

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