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MM-398 — Competitive Intelligence Brief
phase 3
Liposomal topoisomerase I inhibitor
Topoisomerase I
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
MM-398 (MM-398) — Ipsen. MM-398 is a liposomal formulation of irinotecan that delivers the topoisomerase I inhibitor directly to tumor cells while reducing systemic toxicity.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| MM-398 TARGET | MM-398 | Ipsen | phase 3 | Liposomal topoisomerase I inhibitor | Topoisomerase I | |
| Camptosar | irinotecan | Pfizer | marketed | Topoisomerase Inhibitor | topoisomerase I | 1996-01-01 |
| Idamycin Pfs | IDARUBICIN HYDROCHLORIDE | marketed | Anthracycline Topoisomerase Inhibitor | DNA, topoisomerase II | 1990-01-01 | |
| Idamycin Pfs | Idarubicin Hydrochloride | Pfizer Inc. | marketed | Anthracycline topoisomerase inhibitor | DNA, Topoisomerase II | 1990-01-01 |
| Idamycin Pfs | Idarubicin Hydrochloride | Pfizer Inc. | marketed | Anthracycline topoisomerase inhibitor | DNA, Topoisomerase II | 1990-01-01 |
| Cipro | ciprofloxacin | Bayer AG | marketed | Fluoroquinolone antibiotic | DNA topoisomerase II, DNA gyrase subunit A, DNA gyrase subunit A | 1987-10-22 |
| Amekrin | AMSACRINE | marketed | amsacrine | DNA topoisomerase 2-beta, Solute carrier family 22 member 1, DNA topoisomerase II | 1987-01-01 |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
- — Cipro · 11369566 · Formulation · US
- — Cipro · 9603796 · Compound · US
- — Cipro · 9205048 · Method of Use · US
- — Cipro · 9233068 · Formulation · US
- — Cipro · 8318817 · Method of Use · US
- — Cipro · 9220796 · Formulation · US
- — Cipro · 11040004 · Method of Use · US
- — Cipro · 11246863 · Formulation · US
Sponsor landscape (Liposomal topoisomerase I inhibitor class)
- Ipsen · 1 drug in this class
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Cite this brief
Drug Landscape (2026). MM-398 — Competitive Intelligence Brief. https://druglandscape.com/ci/mm-398. Accessed 2026-05-13.
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