Who are Methotrexate and folic acid's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Methotrexate Monotherapy, Methotrexate (tapering dose), Methotrexate tablets, Placebo to Methotrexate.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-17 · How we verify

Methotrexate and folic acid — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Methotrexate and folic acid (Methotrexate and folic acid) competitive landscape: 4 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antimetabolite / Folate antagonist. Area: Oncology / Immunology / Rheumatology.

phase 3 Antimetabolite / Folate antagonist Dihydrofolate reductase (DHFR) Oncology / Immunology / Rheumatology Small molecule Live · refreshed every 30 min

Target snapshot

Methotrexate and folic acid (Methotrexate and folic acid) — University Health Network, Toronto. Methotrexate inhibits dihydrofolate reductase to suppress cell proliferation and immune activation, while folic acid supplementation mitigates methotrexate-induced folate deficiency and toxicity.

Comparator set (4 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Methotrexate and folic acid TARGET	Methotrexate and folic acid	University Health Network, Toronto	phase 3	Antimetabolite / Folate antagonist	Dihydrofolate reductase (DHFR)
Methotrexate Monotherapy	Methotrexate Monotherapy	Bangladesh Medical University	marketed	Antimetabolite / Folate antagonist	Dihydrofolate reductase (DHFR)
Methotrexate (tapering dose)	Methotrexate (tapering dose)	Hoffmann-La Roche	marketed	Antimetabolite / Folate antagonist	Dihydrofolate reductase (DHFR)
Methotrexate tablets	Methotrexate tablets	Yancheng First People's Hospital	marketed	Antimetabolite / Folate antagonist	Dihydrofolate reductase (DHFR)
Placebo to Methotrexate	Placebo to Methotrexate	Amgen	phase 3	Antimetabolite / Folate antagonist	Dihydrofolate reductase (DHFR)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antimetabolite / Folate antagonist class)

Amgen · 1 drug in this class
Bangladesh Medical University · 1 drug in this class
Hoffmann-La Roche · 1 drug in this class
University Health Network, Toronto · 1 drug in this class
Yancheng First People's Hospital · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Methotrexate and folic acid — Competitive Intelligence Brief. https://druglandscape.com/ci/methotrexate-and-folic-acid. Accessed 2026-05-17.

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