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Loceryl NL + Cosmetic varnish — Competitive Intelligence Brief
marketed
Morpholine antifungal
Δ14-steroid reductase and Δ8→Δ7-isomerase (ergosterol biosynthesis pathway)
Dermatology
Small molecule
Live · refreshed every 30 min
Target snapshot
Loceryl NL + Cosmetic varnish (Loceryl NL + Cosmetic varnish) — Galderma R&D. Amorolfine is a morpholine antifungal that inhibits fungal sterol synthesis by blocking both Δ14-reductase and Δ8-Δ7-isomerase enzymes in the ergosterol biosynthesis pathway.
Comparator set (3 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Loceryl NL + Cosmetic varnish TARGET | Loceryl NL + Cosmetic varnish | Galderma R&D | marketed | Morpholine antifungal | Δ14-steroid reductase and Δ8→Δ7-isomerase (ergosterol biosynthesis pathway) | |
| Loceryl NL 15 months | Loceryl NL 15 months | Galderma R&D | marketed | Morpholine antifungal | Fungal sterol synthesis enzymes (Δ14-reductase, Δ8-Δ7-isomerase) | |
| Amorolfine (Antifungal) | Amorolfine (Antifungal) | Pierre Fabre Dermo Cosmetique | marketed | Morpholine antifungal | Lanosterol 14α-demethylase (CYP51) | |
| Loceryl Nail Lacquer | Loceryl Nail Lacquer | Galderma R&D | marketed | Morpholine antifungal | Lanosterol 14α-demethylase (CYP51) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Morpholine antifungal class)
- Galderma R&D · 3 drugs in this class
- Pierre Fabre Dermo Cosmetique · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Loceryl NL + Cosmetic varnish — Competitive Intelligence Brief. https://druglandscape.com/ci/loceryl-nl-cosmetic-varnish. Accessed 2026-05-16.
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