Who are Leucovorin calcium/Levoleucovorin's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Calcium folinate (LV), Levo-Leucovorin, L-leucovorin, L-folinic, L-folinic acid.

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Last reviewed 2026-05-17 · How we verify

Leucovorin calcium/Levoleucovorin — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Leucovorin calcium/Levoleucovorin (Leucovorin calcium/Levoleucovorin) competitive landscape: 5 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Reduced folate cofactor; chemotherapy adjuvant. Area: Oncology.

phase 3 Reduced folate cofactor; chemotherapy adjuvant Thymidylate synthase (indirect); folate metabolism pathway Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Leucovorin calcium/Levoleucovorin (Leucovorin calcium/Levoleucovorin) — Janssen Research & Development, LLC. Leucovorin calcium and levoleucovorin are reduced folate cofactors that enhance the efficacy of antimetabolite chemotherapy agents by providing essential one-carbon units for nucleotide synthesis.

Comparator set (5 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Leucovorin calcium/Levoleucovorin TARGET	Leucovorin calcium/Levoleucovorin	Janssen Research & Development, LLC	phase 3	Reduced folate cofactor; chemotherapy adjuvant	Thymidylate synthase (indirect); folate metabolism pathway
Calcium folinate (LV)	Calcium folinate (LV)	Multicenter Clinical Study Group of Osaka, Colorectal Cancer Treatment Group	phase 3	Reduced folate cofactor / Chemotherapy adjuvant	Thymidylate synthase (indirect, via 5-FU potentiation)
Levo-Leucovorin	Levo-Leucovorin	Fujian Cancer Hospital	phase 3	Reduced folate cofactor / Chemotherapy adjuvant	Thymidylate synthase (indirect)
L-leucovorin	L-leucovorin	Gruppo Oncologico del Nord-Ovest	phase 3	Reduced folate cofactor / chemotherapy adjuvant	Thymidylate synthase (indirect; acts as cofactor)
L-folinic	L-folinic	UNICANCER	phase 3	Reduced folate cofactor / Chemotherapy adjuvant	Thymidylate synthase (indirect)
L-folinic acid	L-folinic acid	The Christie NHS Foundation Trust	phase 3	Reduced folate cofactor / Chemotherapy adjuvant	Thymidylate synthase (indirect), one-carbon metabolism

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Reduced folate cofactor; chemotherapy adjuvant class)

Janssen Research & Development, LLC · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Leucovorin calcium/Levoleucovorin — Competitive Intelligence Brief. https://druglandscape.com/ci/leucovorin-calcium-levoleucovorin. Accessed 2026-05-17.

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