Lasix 25 — Competitive Intelligence Brief

Lasix 25 (Lasix 25) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Loop diuretic. Area: Cardiovascular.

marketed Loop diuretic Na-K-2Cl cotransporter (NKCC2) Cardiovascular Small molecule

Target snapshot

Lasix 25 (Lasix 25) — Heart Care Foundation. Lasix (furosemide) is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Lasix 25 TARGET	Lasix 25	Heart Care Foundation	marketed	Loop diuretic	Na-K-2Cl cotransporter (NKCC2)
TORSEMIDE	TORSEMIDE		marketed	Loop Diuretic [EPC]	Na+/K+/2Cl- carrier system	1993-01-01
Bumex	BUMETANIDE		marketed	Loop Diuretic [EPC]	Solute carrier family 12 member 1	1983-01-01
Edecrin	ETHACRYNIC ACID	Bausch Health	marketed	Loop Diuretic [EPC]	Glutathione S-transferase P	1967-01-01
Lasix	furosemide	Generic (originally Hoechst AG)	marketed	Loop Diuretic [EPC]	ATP-binding cassette sub-family G member 2, CDGSH iron-sulfur domain-containing protein 1, G-protein coupled receptor 35	1966-07-01
FUROSEMIDE	FUROSEMIDE		marketed	Loop Diuretic [EPC]		1966-01-01
Spironolactone and furosemide	Spironolactone and furosemide	University of Padova	marketed	Combination diuretic (potassium-sparing diuretic + loop diuretic)	Aldosterone receptor (spironolactone); Na-K-Cl cotransporter (furosemide)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

• 2033-10-06 — TORSEMIDE · 10154963 · Formulation · US
• 2034-04-03 — Lasix · 9884039 · Method of Use · US
• 2034-04-03 — Lasix · 11433044 · Method of Use · US
• 2034-04-03 — Lasix · 12370168 · Formulation · US
• 2034-04-03 — Lasix · 10272064 · Formulation · US
• 2040-12-04 — Bumex · 11123319 · Formulation · US
• 2040-12-04 — Bumex · 11260038 · Method of Use · US
• 2040-12-04 — Bumex · 12329731 · Formulation · US

Sponsor landscape (Loop diuretic class)

1. Sarfez Pharmaceuticals, Inc. · 3 drugs in this class
2. B&A Therapeutics · 1 drug in this class
3. Jose J Zaragoza, MD MSc · 1 drug in this class
4. Ferrer Internacional S.A. · 1 drug in this class
5. Heart Care Foundation · 1 drug in this class
6. Instituto de Investigación Sanitaria Aragón · 1 drug in this class
7. China National Center for Cardiovascular Diseases · 1 drug in this class
8. Lakeland Regional Health Systems, Inc. · 1 drug in this class
9. Larissa University Hospital · 1 drug in this class
10. Assistance Publique - Hôpitaux de Paris · 1 drug in this class