Who are Kalydeco's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Trikafta (Copackaged), Kalydeco, TEZ, Ivacaftor and Symdeko, Initiation of CFTR Modulator, Elexacaftor / Ivacaftor / Tezacaftor.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

Kalydeco — Competitive Intelligence Brief

Kalydeco (Kalydeco) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Area: Respiratory.

marketed Cystic fibrosis transmembrane conductance regulator Respiratory Small molecule Live · refreshed every 30 min

Target snapshot

Kalydeco (Kalydeco) — Concert Pharmaceuticals.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Kalydeco TARGET	Kalydeco	Concert Pharmaceuticals	marketed		Cystic fibrosis transmembrane conductance regulator
Trikafta (Copackaged)	ELEXACAFTOR	Vertex Pharms Inc	marketed		Cystic fibrosis transmembrane conductance regulator	2019-01-01
Kalydeco	IVACAFTOR	Vertex Pharms Inc	marketed	Cystic Fibrosis Transmembrane Conductance Regulator Potentiator [EPC]	Cystic fibrosis transmembrane conductance regulator	2012-01-01
TEZ	TEZ	Vertex Pharmaceuticals Incorporated	marketed	CFTR corrector	CFTR (cystic fibrosis transmembrane conductance regulator)
Ivacaftor and Symdeko	Ivacaftor and Symdeko	University of Alabama at Birmingham	marketed	CFTR modulator (potentiator and corrector combination)	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
Initiation of CFTR Modulator	Initiation of CFTR Modulator	Children's Hospital Medical Center, Cincinnati	marketed	CFTR modulator	CFTR (cystic fibrosis transmembrane conductance regulator)
Elexacaftor / Ivacaftor / Tezacaftor	Elexacaftor / Ivacaftor / Tezacaftor	Nottingham University Hospitals NHS Trust	marketed	CFTR modulator combination (correctors + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2026-07-06 — Trikafta (Copackaged) · 8354427 · US
2026-12-28 — Trikafta (Copackaged) · 8410274 · US
2026-12-28 — Trikafta (Copackaged) · 9931334 · US
2026-12-28 — Trikafta (Copackaged) · 9670163 · US
2026-12-28 — Trikafta (Copackaged) · 8754224 · US
2027-04-09 — Trikafta (Copackaged) · 10239867 · US
2027-04-09 — Trikafta (Copackaged) · 9974781 · US
2027-04-09 — Trikafta (Copackaged) · 11639347 · US
2027-04-09 — Trikafta (Copackaged) · 10022352 · US
2027-05-01 — Trikafta (Copackaged) · 7645789 · US
2027-05-01 — Trikafta (Copackaged) · 8598181 · US
2027-05-01 — Trikafta (Copackaged) · 8623905 · US
2027-05-20 — Trikafta (Copackaged) · 7495103 · US
2027-06-03 — Trikafta (Copackaged) · 7776905 · US
2027-08-05 — Trikafta (Copackaged) · 8324242 · US
2027-11-12 — Trikafta (Copackaged) · 8415387 · US
2029-08-13 — Trikafta (Copackaged) · 10646481 · US
2029-08-13 — Trikafta (Copackaged) · 11564916 · US
2031-03-25 — Trikafta (Copackaged) · 11578062 · US
2031-03-25 — Trikafta (Copackaged) · 10081621 · US
2033-02-27 — Trikafta (Copackaged) · 8883206 · US
2033-02-27 — Trikafta (Copackaged) · 11147770 · US
2033-02-27 — Trikafta (Copackaged) · 10272046 · US
2033-07-15 — Trikafta (Copackaged) · 9012496 · US
2035-10-06 — Trikafta (Copackaged) · 11426407 · US
2035-10-06 — Trikafta (Copackaged) · 10758534 · US
2037-12-08 — Trikafta (Copackaged) · 11517564 · US
2037-12-08 — Trikafta (Copackaged) · 11453655 · US
2037-12-08 — Trikafta (Copackaged) · 10793547 · US
2037-12-08 — Trikafta (Copackaged) · 11179367 · US

Sponsor landscape

No sponsor landscape data.

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Cite this brief

Drug Landscape (2026). Kalydeco — Competitive Intelligence Brief. https://druglandscape.com/ci/kalydeco. Accessed 2026-05-13.

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