Who are Ivacaftor+lumacaftor's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): LUM/IVA, Lumacaftor plus Ivacaftor, Placebo matched to VX-661/ ivacaftor.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Ivacaftor+lumacaftor — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ivacaftor+lumacaftor (Ivacaftor+lumacaftor) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: CFTR modulator combination (corrector + potentiator). Area: Respiratory / Genetic disease.

marketed CFTR modulator combination (corrector + potentiator) CFTR (cystic fibrosis transmembrane conductance regulator) Respiratory / Genetic disease Small molecule Live · refreshed every 30 min

Target snapshot

Ivacaftor+lumacaftor (Ivacaftor+lumacaftor) — Assistance Publique - Hôpitaux de Paris. Lumacaftor corrects the trafficking of defective CFTR protein to the cell surface, while ivacaftor enhances the channel activity of CFTR, together restoring chloride transport in cystic fibrosis.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Ivacaftor+lumacaftor TARGET	Ivacaftor+lumacaftor	Assistance Publique - Hôpitaux de Paris	marketed	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
LUM/IVA	LUM/IVA	Vertex Pharmaceuticals Incorporated	marketed	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Lumacaftor plus Ivacaftor	Lumacaftor plus Ivacaftor	Hannover Medical School	phase 3	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Placebo matched to VX-661/ ivacaftor	Placebo matched to VX-661/ ivacaftor	Vertex Pharmaceuticals Incorporated	phase 3	CFTR modulator combination (corrector + potentiator)	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (CFTR modulator combination (corrector + potentiator) class)

Vertex Pharmaceuticals Incorporated · 2 drugs in this class
Assistance Publique - Hôpitaux de Paris · 1 drug in this class
Hannover Medical School · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Ivacaftor+lumacaftor — Competitive Intelligence Brief. https://druglandscape.com/ci/ivacaftor-lumacaftor. Accessed 2026-05-16.

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