iso sorbide dinitrate iv bolus or s/l — Competitive Intelligence Brief

iso sorbide dinitrate iv bolus or s/l (iso sorbide dinitrate iv bolus or s/l) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Nitrate vasodilator. Area: Cardiovascular.

marketed Nitrate vasodilator Guanylate cyclase (via nitric oxide) Cardiovascular Small molecule

Target snapshot

iso sorbide dinitrate iv bolus or s/l (iso sorbide dinitrate iv bolus or s/l) — Soroka University Medical Center. Isosorbide dinitrate is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and reduce cardiac preload and afterload.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
iso sorbide dinitrate iv bolus or s/l TARGET	iso sorbide dinitrate iv bolus or s/l	Soroka University Medical Center	marketed	Nitrate vasodilator	Guanylate cyclase (via nitric oxide)
Monoket	ISOSORBIDE MONONITRATE		marketed	Nitrate Vasodilator [EPC]	Atrial natriuretic peptide receptor 1	1991-01-01
NITROGLYCERIN	NITROGLYCERIN		marketed	Nitrate Vasodilator [EPC]	Nitric oxide synthase pathway	1981-01-01
Nitroglycerin	glyceryl trinitrate	Fougera	marketed	Nitrate Vasodilator [EPC]	guanylate cyclase	1981-01-01
Isobide	ISOSORBIDE	Novartis	marketed	Nitrate Vasodilator [EPC]		1974-01-01
Topical Nitroglycerine	Topical Nitroglycerine	Aultman Health Foundation	marketed	Nitrate vasodilator	Soluble guanylate cyclase (via nitric oxide)
Low-concentration carbohydrate and nitrates	Low-concentration carbohydrate and nitrates	Ain Shams University	marketed	Combination therapy (carbohydrate + nitrate vasodilator)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

• 2029-03-12 — Nitroglycerin · 7872049 · US
• 2029-03-12 — NITROGLYCERIN · 7872049 · Formulation · US
• 2032-03-11 — Nitroglycerin · 9101592 · US
• 2032-03-11 — NITROGLYCERIN · 9101592 · Formulation · US

Sponsor landscape (Nitrate vasodilator class)

1. Aultman Health Foundation · 1 drug in this class
2. Bristol-Myers Squibb · 1 drug in this class
3. GF Strong Rehabilitation Centre · 1 drug in this class
4. Instituto de Cardiologia de Santa Catarina · 1 drug in this class
5. MediQuest Therapeutics · 1 drug in this class
6. Ohio State University · 1 drug in this class
7. Onze Lieve Vrouwe Gasthuis · 1 drug in this class
8. Pfizer's Upjohn has merged with Mylan to form Viatris Inc. · 1 drug in this class
9. Recep Tayyip Erdogan University · 1 drug in this class
10. Soroka University Medical Center · 1 drug in this class