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Topical Nitroglycerine
Topical nitroglycerin releases nitric oxide, which relaxes vascular smooth muscle and improves blood flow to the affected area.
Topical nitroglycerin releases nitric oxide, which relaxes vascular smooth muscle and improves blood flow to the affected area. Used for Angina pectoris, Topical ischemic conditions and wound healing, Anal fissures (off-label use).
At a glance
| Generic name | Topical Nitroglycerine |
|---|---|
| Also known as | Vasodilation |
| Sponsor | Aultman Health Foundation |
| Drug class | Nitrate vasodilator |
| Target | Soluble guanylate cyclase (via nitric oxide) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular; Dermatology; Wound care |
| Phase | FDA-approved |
Mechanism of action
Nitroglycerin is a nitrate vasodilator that is bioconverted to nitric oxide (NO), a potent vasodilator. When applied topically, it penetrates the skin and causes relaxation of vascular smooth muscle in the underlying tissues, increasing blood flow and oxygen delivery. This mechanism is used therapeutically to relieve angina, improve wound healing, and reduce pain in conditions with compromised local circulation.
Approved indications
- Angina pectoris
- Topical ischemic conditions and wound healing
- Anal fissures (off-label use)
Common side effects
- Headache
- Dizziness
- Hypotension
- Flushing
- Contact dermatitis
Key clinical trials
- Glyceryl Trinitrate Gel Phonophoresis on Planter Fasciiatis (NA)
- Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow (PHASE3)
- Nitroglycerin Ointment for Pain Relief After Endoscopic Hemorrhoid Band Ligation (PHASE4)
- Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging. (PHASE1)
- "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy") (NA)
- Effect of Stellate Ganglion Block on Internal Mammary Artery Dynamics (NA)
- Topical Nitroglycerine for Prevention of Radial Artery Spasm (PHASE3)
- Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Topical Nitroglycerine CI brief — competitive landscape report
- Topical Nitroglycerine updates RSS · CI watch RSS
- Aultman Health Foundation portfolio CI