Who are Irinotecan/Tegafur's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Irinotecan, 5FU, leucovorin, Irinotecan liposome、5-Fluorouracil、Leucovorin, Irinotecan + 5 FU + folinic acid.

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Last reviewed 2026-06-10 · How we verify

Irinotecan/Tegafur — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Irinotecan/Tegafur (Irinotecan/Tegafur) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Topoisomerase I inhibitor + Fluoropyrimidine antimetabolite combination. Area: Oncology.

phase 3 Topoisomerase I inhibitor + Fluoropyrimidine antimetabolite combination Topoisomerase I; Thymidylate synthase Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Irinotecan/Tegafur (Irinotecan/Tegafur) — Sunshine Lake Pharma Co., Ltd.. Irinotecan inhibits topoisomerase I to prevent DNA unwinding during replication, while tegafur is a prodrug of fluorouracil that inhibits thymidylate synthase to disrupt nucleotide synthesis.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Irinotecan/Tegafur TARGET	Irinotecan/Tegafur	Sunshine Lake Pharma Co., Ltd.	phase 3	Topoisomerase I inhibitor + Fluoropyrimidine antimetabolite combination	Topoisomerase I; Thymidylate synthase
Irinotecan, 5FU, leucovorin	Irinotecan, 5FU, leucovorin	Asan Medical Center	marketed	Chemotherapy combination (topoisomerase I inhibitor + antimetabolite)	Topoisomerase I; thymidylate synthase
Irinotecan liposome、5-Fluorouracil、Leucovorin	Irinotecan liposome、5-Fluorouracil、Leucovorin	Jiangsu HengRui Medicine Co., Ltd.	phase 3	Combination chemotherapy (topoisomerase I inhibitor + antimetabolite)	Topoisomerase I; thymidylate synthase
Irinotecan + 5 FU + folinic acid	Irinotecan + 5 FU + folinic acid	Pfizer	phase 3	Combination chemotherapy (topoisomerase I inhibitor + antimetabolite)	Topoisomerase I; Thymidylate synthase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Topoisomerase I inhibitor + Fluoropyrimidine antimetabolite combination class)

Sunshine Lake Pharma Co., Ltd. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Irinotecan/Tegafur — Competitive Intelligence Brief. https://druglandscape.com/ci/irinotecan-tegafur. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing