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Irinotecan liposome、5-Fluorouracil、Leucovorin
Irinotecan liposome、5-Fluorouracil、Leucovorin is a Combination chemotherapy (topoisomerase I inhibitor + antimetabolite) Small molecule drug developed by Jiangsu HengRui Medicine Co., Ltd.. It is currently in Phase 3 development for Metastatic colorectal cancer, Pancreatic cancer (in development).
This combination regimen uses liposomal irinotecan (a topoisomerase I inhibitor) plus 5-fluorouracil and leucovorin to inhibit DNA replication and repair in cancer cells.
This combination regimen uses liposomal irinotecan (a topoisomerase I inhibitor) plus 5-fluorouracil and leucovorin to inhibit DNA replication and repair in cancer cells. Used for Metastatic colorectal cancer, Pancreatic cancer (in development).
At a glance
| Generic name | Irinotecan liposome、5-Fluorouracil、Leucovorin |
|---|---|
| Sponsor | Jiangsu HengRui Medicine Co., Ltd. |
| Drug class | Combination chemotherapy (topoisomerase I inhibitor + antimetabolite) |
| Target | Topoisomerase I; thymidylate synthase |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Irinotecan is a camptothecin derivative that inhibits topoisomerase I, preventing DNA unwinding and causing cell death. The liposomal formulation improves drug delivery and reduces systemic toxicity. 5-Fluorouracil is an antimetabolite that inhibits thymidylate synthase and incorporates into DNA/RNA, while leucovorin (folinic acid) enhances 5-FU efficacy by stabilizing the FdUMP-thymidylate synthase complex.
Approved indications
- Metastatic colorectal cancer
- Pancreatic cancer (in development)
Common side effects
- Neutropenia
- Diarrhea
- Nausea/vomiting
- Anemia
- Fatigue
- Mucositis
- Thrombocytopenia
Key clinical trials
- Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations (PHASE3)
- Oxaliplatin Combined With Irinotecan Liposome Injection II Through Hepatic Artery Infusion (HAIC) Followed by 5-FU/LV (HAIC) or Tegorgor Oral Combination Therapy for Hepatic Metastasis of Pancreatic Cancer (PHASE2)
- A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer (PHASE3)
- Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread (PHASE2)
- Monthly Alternating NALIRIFOX and GnP in the First-Line Setting for Metastatic Pancreatic Ductal Adenocarcinoma (PHASE2)
- A Study of Suizenji in Patients With Unresectable Pancreatic Cancer (NA)
- A Study to Assess the Effectiveness and Safety of Irinotecan Liposome Injection, 5-fluorouracil/Leucovorin Plus Oxaliplatin in Patients Not Previously Treated for Metastatic Pancreatic Cancer, Compared to Nab-paclitaxel+Gemcitabine Treatment (PHASE3)
- A Study of ASP3082 in Adults With Advanced Solid Tumors (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Irinotecan liposome、5-Fluorouracil、Leucovorin CI brief — competitive landscape report
- Irinotecan liposome、5-Fluorouracil、Leucovorin updates RSS · CI watch RSS
- Jiangsu HengRui Medicine Co., Ltd. portfolio CI
Frequently asked questions about Irinotecan liposome、5-Fluorouracil、Leucovorin
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Related
- Drug class: All Combination chemotherapy (topoisomerase I inhibitor + antimetabolite) drugs
- Target: All drugs targeting Topoisomerase I; thymidylate synthase
- Manufacturer: Jiangsu HengRui Medicine Co., Ltd. — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Metastatic colorectal cancer
- Indication: Drugs for Pancreatic cancer (in development)
- Compare: Irinotecan liposome、5-Fluorouracil、Leucovorin vs similar drugs
- Pricing: Irinotecan liposome、5-Fluorouracil、Leucovorin cost, discount & access