Who are Irinotecan, 5FU, leucovorin's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Irinotecan + 5 FU + folinic acid, Irinotecan liposome、5-Fluorouracil、Leucovorin, Irinotecan/Tegafur.

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Last reviewed 2026-05-17 · How we verify

Irinotecan, 5FU, leucovorin — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Irinotecan, 5FU, leucovorin (Irinotecan, 5FU, leucovorin) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Chemotherapy combination (topoisomerase I inhibitor + antimetabolite). Area: Oncology.

marketed Chemotherapy combination (topoisomerase I inhibitor + antimetabolite) Topoisomerase I; thymidylate synthase Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Irinotecan, 5FU, leucovorin (Irinotecan, 5FU, leucovorin) — Asan Medical Center. This combination chemotherapy regimen inhibits DNA synthesis and cell division through topoisomerase I inhibition and fluoropyrimidine-mediated nucleotide antagonism.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Irinotecan, 5FU, leucovorin TARGET	Irinotecan, 5FU, leucovorin	Asan Medical Center	marketed	Chemotherapy combination (topoisomerase I inhibitor + antimetabolite)	Topoisomerase I; thymidylate synthase
Irinotecan + 5 FU + folinic acid	Irinotecan + 5 FU + folinic acid	Pfizer	phase 3	Combination chemotherapy (topoisomerase I inhibitor + antimetabolite)	Topoisomerase I; Thymidylate synthase
Irinotecan liposome、5-Fluorouracil、Leucovorin	Irinotecan liposome、5-Fluorouracil、Leucovorin	Jiangsu HengRui Medicine Co., Ltd.	phase 3	Combination chemotherapy (topoisomerase I inhibitor + antimetabolite)	Topoisomerase I; thymidylate synthase
Irinotecan/Tegafur	Irinotecan/Tegafur	Sunshine Lake Pharma Co., Ltd.	phase 3	Topoisomerase I inhibitor + Fluoropyrimidine antimetabolite combination	Topoisomerase I; Thymidylate synthase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Chemotherapy combination (topoisomerase I inhibitor + antimetabolite) class)

Asan Medical Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Irinotecan, 5FU, leucovorin — Competitive Intelligence Brief. https://druglandscape.com/ci/irinotecan-5fu-leucovorin. Accessed 2026-05-17.

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