Who are Irinotecan + 5 FU + folinic acid's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Irinotecan, 5FU, leucovorin, Irinotecan/Tegafur, Irinotecan liposome、5-Fluorouracil、Leucovorin.

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Last reviewed 2026-05-17 · How we verify

Irinotecan + 5 FU + folinic acid — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Irinotecan + 5 FU + folinic acid (Irinotecan + 5 FU + folinic acid) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Combination chemotherapy (topoisomerase I inhibitor + antimetabolite). Area: Oncology.

phase 3 Combination chemotherapy (topoisomerase I inhibitor + antimetabolite) Topoisomerase I; Thymidylate synthase Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Irinotecan + 5 FU + folinic acid (Irinotecan + 5 FU + folinic acid) — Pfizer. This combination chemotherapy regimen kills cancer cells by inhibiting topoisomerase I (irinotecan) and blocking thymidylate synthase (5-FU with folinic acid potentiation).

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Irinotecan + 5 FU + folinic acid TARGET	Irinotecan + 5 FU + folinic acid	Pfizer	phase 3	Combination chemotherapy (topoisomerase I inhibitor + antimetabolite)	Topoisomerase I; Thymidylate synthase
Irinotecan, 5FU, leucovorin	Irinotecan, 5FU, leucovorin	Asan Medical Center	marketed	Chemotherapy combination (topoisomerase I inhibitor + antimetabolite)	Topoisomerase I; thymidylate synthase
Irinotecan/Tegafur	Irinotecan/Tegafur	Sunshine Lake Pharma Co., Ltd.	phase 3	Topoisomerase I inhibitor + Fluoropyrimidine antimetabolite combination	Topoisomerase I; Thymidylate synthase
Irinotecan liposome、5-Fluorouracil、Leucovorin	Irinotecan liposome、5-Fluorouracil、Leucovorin	Jiangsu HengRui Medicine Co., Ltd.	phase 3	Combination chemotherapy (topoisomerase I inhibitor + antimetabolite)	Topoisomerase I; thymidylate synthase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Combination chemotherapy (topoisomerase I inhibitor + antimetabolite) class)

Jiangsu HengRui Medicine Co., Ltd. · 1 drug in this class
Pfizer · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Irinotecan + 5 FU + folinic acid — Competitive Intelligence Brief. https://druglandscape.com/ci/irinotecan-5-fu-folinic-acid. Accessed 2026-05-17.

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