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Intravenous iclaprim — Competitive Intelligence Brief

Intravenous iclaprim (Intravenous iclaprim) competitive landscape: 4 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Dihydrofolate reductase inhibitor. Area: Infectious Disease.

phase 3 Dihydrofolate reductase inhibitor Dihydrofolate reductase (DHFR) Infectious Disease Small molecule Live · refreshed every 30 min

Target snapshot

Intravenous iclaprim (Intravenous iclaprim) — Arpida AG. Iclaprim is a dihydrofolate reductase (DHFR) inhibitor that disrupts bacterial folate metabolism, preventing DNA synthesis and bacterial growth.

Comparator set (4 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

DrugGenericSponsorPhaseClassTargetApproval / PDUFA
Intravenous iclaprim TARGET Intravenous iclaprim Arpida AG phase 3 Dihydrofolate reductase inhibitor Dihydrofolate reductase (DHFR)
Sulfamethoxazole / Trimethoprim Injectable Product Sulfamethoxazole / Trimethoprim Injectable Product Fundacion Clinic per a la Recerca Biomédica marketed Sulfonamide + dihydrofolate reductase inhibitor combination Dihydropteroate synthase and dihydrofolate reductase
Sulfamethoxazole Trimethoprim Combination Sulfamethoxazole Trimethoprim Combination Baylor Research Institute marketed Sulfonamide-dihydrofolate reductase inhibitor combination Dihydropteroate synthase; Dihydrofolate reductase
Sulfamethoxazole-Trimethoprim Sulfamethoxazole-Trimethoprim National Institute of Allergy and Infectious Diseases (NIAID) marketed Sulfonamide-dihydrofolate reductase inhibitor combination Dihydropteroate synthase; Dihydrofolate reductase
SMZ/TMP SMZ/TMP First Affiliated Hospital of Zhejiang University phase 3 Sulfonamide and dihydrofolate reductase inhibitor combination

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Dihydrofolate reductase inhibitor class)

  1. Arpida AG · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Intravenous iclaprim — Competitive Intelligence Brief. https://druglandscape.com/ci/intravenous-iclaprim. Accessed 2026-05-17.

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