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Induction Cycles A4-5 — Competitive Intelligence Brief
phase 3
Multi-agent chemotherapy regimen
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Induction Cycles A4-5 (Induction Cycles A4-5) — Nationwide Children's Hospital. Induction Cycles A4-5 is a chemotherapy regimen designed to induce remission in pediatric leukemia patients through sequential administration of multiple cytotoxic agents.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Induction Cycles A4-5 TARGET | Induction Cycles A4-5 | Nationwide Children's Hospital | phase 3 | Multi-agent chemotherapy regimen | ||
| HDS vs ProMECE/CytaBOM | HDS vs ProMECE/CytaBOM | Gruppo Italiano Studio Linfomi | phase 3 | Multi-agent chemotherapy regimen | ||
| Methotrexate, Cyclophosphamide, Cytarabine, Etoposide | Methotrexate, Cyclophosphamide, Cytarabine, Etoposide | St. Jude Children's Research Hospital | phase 3 | Multi-agent chemotherapy regimen | ||
| Course B1 +Vin | Course B1 +Vin | Children's Cancer Group, China | phase 3 | Multi-agent chemotherapy regimen | ||
| A arm (CLAG-M) | A arm (CLAG-M) | Polish Adult Leukemia Group | phase 3 | Multi-agent chemotherapy regimen | ||
| Cladribine, Cyclophosphamide, Cytarabine, Daunorubicin, Dexamethasone | Cladribine, Cyclophosphamide, Cytarabine, Daunorubicin, Dexamethasone | St. Jude Children's Research Hospital | phase 3 | Multi-agent chemotherapy regimen | ||
| Prednisone, Dexamethasone, Vincristine, Daunorubicin | Prednisone, Dexamethasone, Vincristine, Daunorubicin | St. Jude Children's Research Hospital | phase 3 | Multi-agent chemotherapy regimen |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Multi-agent chemotherapy regimen class)
- St. Jude Children's Research Hospital · 3 drugs in this class
- Nationwide Children's Hospital · 2 drugs in this class
- SWOG Cancer Research Network · 2 drugs in this class
- Children's Cancer Group, China · 1 drug in this class
- Gruppo Italiano Studio Linfomi · 1 drug in this class
- Polish Adult Leukemia Group · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Induction Cycles A4-5 — Competitive Intelligence Brief. https://druglandscape.com/ci/induction-cycles-a4-5. Accessed 2026-05-13.
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