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Prednisone, Dexamethasone, Vincristine, Daunorubicin
Prednisone, Dexamethasone, Vincristine, Daunorubicin is a Multi-agent chemotherapy regimen Small molecule drug developed by St. Jude Children's Research Hospital. It is currently in Phase 3 development for Acute lymphoblastic leukemia (ALL) in children, Acute myeloid leukemia (AML) in children.
This is a multi-drug chemotherapy regimen that combines corticosteroid immunosuppression, alkylating agents, and cytotoxic chemotherapy to treat acute leukemia by suppressing immune response and killing rapidly dividing cancer cells.
This is a multi-drug chemotherapy regimen that combines corticosteroid immunosuppression, alkylating agents, and cytotoxic chemotherapy to treat acute leukemia by suppressing immune response and killing rapidly dividing cancer cells. Used for Acute lymphoblastic leukemia (ALL) in children, Acute myeloid leukemia (AML) in children.
At a glance
| Generic name | Prednisone, Dexamethasone, Vincristine, Daunorubicin |
|---|---|
| Sponsor | St. Jude Children's Research Hospital |
| Drug class | Multi-agent chemotherapy regimen |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Prednisone is a corticosteroid that suppresses immune function and reduces inflammation. Dexamethasone is a potent corticosteroid with similar immunosuppressive effects. Vincristine is a vinca alkaloid that arrests cells in metaphase by disrupting microtubule formation. Daunorubicin is an anthracycline that intercalates into DNA and inhibits topoisomerase II, causing DNA damage and cell death. Together, these agents target leukemic blasts through multiple mechanisms.
Approved indications
- Acute lymphoblastic leukemia (ALL) in children
- Acute myeloid leukemia (AML) in children
Common side effects
- Myelosuppression (neutropenia, thrombocytopenia, anemia)
- Infection
- Mucositis
- Nausea and vomiting
- Alopecia
- Cardiotoxicity (daunorubicin-related)
- Peripheral neuropathy (vincristine-related)
- Hyperglycemia (corticosteroid-related)
Key clinical trials
- Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia (PHASE2)
- A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia (PHASE3)
- Pediatric-Inspired Regimen Combined With Venetoclax and Immunotherapy for Adult Ph-Negative Acute Lymphoblastic Leukemia (NA)
- Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia (PHASE2)
- Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults (PHASE3)
- Testing the Addition of an Anti-Cancer Drug, Glofitamab, to the Usual Chemotherapy Treatment (Alternating R-CHOP/R-DHAP) for Previously Untreated Mantle Cell Lymphoma (PHASE1)
- Capizzi Escalating Methotrexate Versus High Dose Methotrexate in Children With Newly Diagnosed T-cell Lymphoblastic Lymphoma (T-LBL) (PHASE3)
- LBL-2016 for Children or Adolescents in China (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Prednisone, Dexamethasone, Vincristine, Daunorubicin CI brief — competitive landscape report
- Prednisone, Dexamethasone, Vincristine, Daunorubicin updates RSS · CI watch RSS
- St. Jude Children's Research Hospital portfolio CI
Frequently asked questions about Prednisone, Dexamethasone, Vincristine, Daunorubicin
What is Prednisone, Dexamethasone, Vincristine, Daunorubicin?
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Who makes Prednisone, Dexamethasone, Vincristine, Daunorubicin?
What drug class is Prednisone, Dexamethasone, Vincristine, Daunorubicin in?
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Related
- Drug class: All Multi-agent chemotherapy regimen drugs
- Manufacturer: St. Jude Children's Research Hospital — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Acute lymphoblastic leukemia (ALL) in children
- Indication: Drugs for Acute myeloid leukemia (AML) in children
- Compare: Prednisone, Dexamethasone, Vincristine, Daunorubicin vs similar drugs
- Pricing: Prednisone, Dexamethasone, Vincristine, Daunorubicin cost, discount & access