Indapamide (T2) — Competitive Intelligence Brief

Indapamide (T2) (Indapamide (T2)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Thiazide-like diuretic. Area: Cardiovascular.

marketed Thiazide-like diuretic Sodium-chloride cotransporter (NCC) Cardiovascular Small molecule

Target snapshot

Indapamide (T2) (Indapamide (T2)) — Hospices Civils de Lyon. Indapamide is a thiazide-like diuretic that inhibits sodium reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Indapamide (T2) TARGET	Indapamide (T2)	Hospices Civils de Lyon	marketed	Thiazide-like diuretic	Sodium-chloride cotransporter (NCC)
Lozol	INDAPAMIDE		marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1983-01-01
Zaroxolyn	METOLAZONE	I3 Pharms	marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1973-01-01
CHLORTHALIDONE	CHLORTHALIDONE		marketed	Thiazide-like Diuretic [EPC]	Na+/Cl− cotransporter	1960-01-01
Combipres	Chlortalidone	University Hospital Birmingham	marketed	Thiazide-like Diuretic	Carbonic anhydrase 7	1960-01-01
Metolazone concurrently with furosemide	Metolazone concurrently with furosemide	University of Maryland, Baltimore	marketed	Thiazide-like diuretic and loop diuretic combination	Sodium-chloride cotransporter (NCC) and sodium-potassium-chloride cotransporter (NKCC2)
Amlodipine + Indapamide	Amlodipine + Indapamide	Centre for Chronic Disease Control, India	marketed	Calcium channel blocker + Thiazide-like diuretic combination	L-type voltage-gated calcium channels (amlodipine); sodium-chloride cotransporter (indapamide)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

• 2028-03-26 — Combipres · 9066936 · US
• 2030-02-04 — Combipres · 9169238 · US
• 2031-07-01 — Combipres · 9387249 · US

Sponsor landscape (Thiazide-like diuretic class)

1. Eurofarma Laboratorios S.A. · 1 drug in this class
2. Farma de Colombia SA · 1 drug in this class
3. Hospices Civils de Lyon · 1 drug in this class
4. NHS Greater Glasgow and Clyde · 1 drug in this class
5. University of North Carolina, Chapel Hill · 1 drug in this class
6. University of Virginia · 1 drug in this class
7. VA Office of Research and Development · 1 drug in this class