Who are H2 Receptor Antagonist's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Axid Ar, Zantac, Histalog, Tagamet, Bentyl, Rosuvastatin-ranitidine.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-17 · How we verify

H2 Receptor Antagonist — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

H2 Receptor Antagonist (H2 Receptor Antagonist) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: H2 receptor antagonist. Area: Gastroenterology.

phase 3 H2 receptor antagonist Histamine H2 receptor Gastroenterology Small molecule Live · refreshed every 30 min

Target snapshot

H2 Receptor Antagonist (H2 Receptor Antagonist) — Merck Sharp & Dohme LLC. H2 receptor antagonists block histamine H2 receptors on gastric parietal cells to reduce stomach acid secretion.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
H2 Receptor Antagonist TARGET	H2 Receptor Antagonist	Merck Sharp & Dohme LLC	phase 3	H2 receptor antagonist	Histamine H2 receptor
Axid Ar	NIZATIDINE		marketed	Histamine-2 Receptor Antagonist [EPC]	Histamine H2 receptor	1988-01-01
Zantac	ranitidine	GSK (originally Glaxo)	marketed	H2 receptor antagonist	Multidrug and toxin extrusion protein 1, Acetylcholinesterase, Histamine H2 receptor	1983-06-01
Histalog	BETAZOLE		marketed	betazole	Histamine H2 receptor	1982-01-01
Tagamet	CIMETIDINE		marketed	Histamine-2 Receptor Antagonist [EPC]	Histamine H2 receptor	1977-01-01
Bentyl	dicycloverine	Forest Labs Inc	marketed	Anticholinergic	Histamine H2 receptor	1950-01-01
Rosuvastatin-ranitidine	Rosuvastatin-ranitidine	Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec	marketed	Fixed-dose combination: HMG-CoA reductase inhibitor + H2-receptor antagonist	HMG-CoA reductase (rosuvastatin component); Histamine H2 receptor (ranitidine component)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (H2 receptor antagonist class)

GSK (originally Glaxo) · 1 drug in this class
Merck Sharp & Dohme LLC · 1 drug in this class
University of Maryland, Baltimore · 1 drug in this class

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Cite this brief

Drug Landscape (2026). H2 Receptor Antagonist — Competitive Intelligence Brief. https://druglandscape.com/ci/h2-receptor-antagonist. Accessed 2026-05-17.

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