Who are H1 antihistamines's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Lastacaft, Xyzal, Elestat, Rupax, Zaditor, Mizollen.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Subscribe to /feed/ci/h1-antihistamines.xml in any RSS reader (Feedly, Inoreader, NewsBlur). Every regulatory action, trial readout, or patent event lands in your feed automatically.

Last reviewed 2026-05-14 · How we verify

H1 antihistamines — Competitive Intelligence Brief

H1 antihistamines (H1 antihistamines) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: H1 receptor antagonist. Area: Respiratory.

phase 2 H1 receptor antagonist H1 receptor Respiratory Small molecule Live · refreshed every 30 min

Target snapshot

H1 antihistamines (H1 antihistamines) — Genentech, Inc.. Blocks H1 histamine receptors

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
H1 antihistamines TARGET	H1 antihistamines	Genentech, Inc.	phase 2	H1 receptor antagonist	H1 receptor
Lastacaft	ALCAFTADINE	AbbVie	marketed	Histamine-1 Receptor Antagonist [EPC]	Histamine H1 receptor	2010-01-01
Xyzal	LEVOCETIRIZINE	Sanofi	marketed	Histamine-1 Receptor Antagonist	Histamine H1 receptor	2007-01-01
Elestat	EPINASTINE	AbbVie	marketed	Adrenergic Receptor Agonist	Histamine H1 receptor	2003-01-01
Rupax	RUPATADINE	Teikoku Seiyaku	marketed	rupatadine	Histamine H1 receptor	2001-01-01
Zaditor	KETOTIFEN		marketed	Histamine-1 Receptor Inhibitor	Histamine H1 receptor	1999-01-01
Mizollen	MIZOLASTINE	Sanofi	marketed	mizolastine	Histamine H1 receptor	1998-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (H1 receptor antagonist class)

Erasmus Medical Center · 1 drug in this class
Faes Farma, S.A. · 1 drug in this class
Farmoquimica S.A. · 1 drug in this class
Genentech, Inc. · 1 drug in this class
Merck Sharp & Dohme LLC · 1 drug in this class

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Cite this brief

Drug Landscape (2026). H1 antihistamines — Competitive Intelligence Brief. https://druglandscape.com/ci/h1-antihistamines. Accessed 2026-05-14.

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