Who are Ismelin's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Dexmedetomidine Hydrochloride, Levadil, Wellbutrin, Hylorel, Methoxamin, MAPROTILINE.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

How do I get this as a recurring report?

Subscribe to /feed/ci/guanethidine.xml in any RSS reader (Feedly, Inoreader, NewsBlur). Every regulatory action, trial readout, or patent event lands in your feed automatically.

Last reviewed 2026-05-13 · How we verify

Ismelin — Competitive Intelligence Brief

Ismelin (GUANETHIDINE) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: guanethidine. Area: Neuroscience.

marketed guanethidine Alpha-1A adrenergic receptor Neuroscience Small molecule Live · refreshed every 30 min

Target snapshot

Ismelin (GUANETHIDINE).

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Ismelin TARGET	GUANETHIDINE		marketed	guanethidine	Alpha-1A adrenergic receptor	1960-01-01
Dexmedetomidine Hydrochloride	dexmedetomidine-hydrochloride	Pfizer	marketed	dexmedetomidine	Alpha-1A adrenergic receptor	1999-01-01
Levadil	DILEVALOL		marketed	dilevalol	Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Beta-1 adrenergic receptor	1990-01-01
Wellbutrin	bupropion	GSK (GlaxoSmithKline)	marketed	NDRI (Norepinephrine-dopamine reuptake inhibitor)	Cytochrome P450 2C19, Neuronal acetylcholine receptor subunit alpha-7, Alpha-1A adrenergic receptor	1985-12-30
Hylorel	GUANADREL	Pfizer	marketed	guanadrel	Alpha-1A adrenergic receptor	1982-01-01
Methoxamin	METHOXAMINE	GSK	marketed	methoxamine	Alpha-1A adrenergic receptor	1982-01-01
MAPROTILINE	MAPROTILINE		marketed	maprotiline	Alpha-1A adrenergic receptor	1980-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2032-01-04 — Dexmedetomidine Hydrochloride · 8242158 · US
2032-01-04 — Dexmedetomidine Hydrochloride · 9616049 · US
2032-01-04 — Dexmedetomidine Hydrochloride · 8648106 · US
2032-01-04 — Dexmedetomidine Hydrochloride · 9320712 · US
2032-01-04 — Dexmedetomidine Hydrochloride · 8455527 · US
2032-01-04 — Dexmedetomidine Hydrochloride · 10016396 · US
2032-01-04 — Dexmedetomidine Hydrochloride · 8338470 · US
2032-07-04 — Dexmedetomidine Hydrochloride · 8242158*PED · US
2032-07-04 — Dexmedetomidine Hydrochloride · 8648106*PED · US
2032-07-04 — Dexmedetomidine Hydrochloride · 8455527*PED · US
2032-07-04 — Dexmedetomidine Hydrochloride · 8338470*PED · US
2032-07-04 — Dexmedetomidine Hydrochloride · 9320712*PED · US
2032-07-04 — Dexmedetomidine Hydrochloride · 9616049*PED · US
2036-04-20 — Dexmedetomidine Hydrochloride · 9717796 · US
2036-04-20 — Dexmedetomidine Hydrochloride · 9649296 · US
2039-06-26 — Dexmedetomidine Hydrochloride · 11517524 · US
2039-06-26 — Dexmedetomidine Hydrochloride · 11497711 · US
2039-06-26 — Dexmedetomidine Hydrochloride · 10792246 · US
2039-06-26 — Dexmedetomidine Hydrochloride · 11478422 · US

Sponsor landscape (guanethidine class)

· 1 drug in this class

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Cite this brief

Drug Landscape (2026). Ismelin — Competitive Intelligence Brief. https://druglandscape.com/ci/guanethidine. Accessed 2026-05-13.

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