GROUP C: Chlorthalidone — Competitive Intelligence Brief

GROUP C: Chlorthalidone (GROUP C: Chlorthalidone) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Thiazide-like diuretic. Area: Cardiovascular.

phase 3 Thiazide-like diuretic Sodium-chloride cotransporter (NCC) Cardiovascular Small molecule

Target snapshot

GROUP C: Chlorthalidone (GROUP C: Chlorthalidone) — Farma de Colombia SA. Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, promoting urinary excretion and reducing blood volume and blood pressure.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
GROUP C: Chlorthalidone TARGET	GROUP C: Chlorthalidone	Farma de Colombia SA	phase 3	Thiazide-like diuretic	Sodium-chloride cotransporter (NCC)
Lozol	INDAPAMIDE		marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1983-01-01
Zaroxolyn	METOLAZONE	I3 Pharms	marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1973-01-01
CHLORTHALIDONE	CHLORTHALIDONE		marketed	Thiazide-like Diuretic [EPC]	Na+/Cl− cotransporter	1960-01-01
Combipres	Chlortalidone	University Hospital Birmingham	marketed	Thiazide-like Diuretic	Carbonic anhydrase 7	1960-01-01
Chlorthalidone with potassium chloride	Chlorthalidone with potassium chloride	Brigham and Women's Hospital	marketed	Thiazide-like diuretic with potassium supplement	Sodium-chloride cotransporter (NCC)
Perindopril + Indapamide	Perindopril + Indapamide	Centre for Chronic Disease Control, India	marketed	ACE inhibitor + thiazide-like diuretic combination	Angiotensin-converting enzyme (ACE); sodium-chloride cotransporter

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

• 2028-03-26 — Combipres · 9066936 · US
• 2030-02-04 — Combipres · 9169238 · US
• 2031-07-01 — Combipres · 9387249 · US

Sponsor landscape (Thiazide-like diuretic class)

1. Eurofarma Laboratorios S.A. · 1 drug in this class
2. Farma de Colombia SA · 1 drug in this class
3. Hospices Civils de Lyon · 1 drug in this class
4. NHS Greater Glasgow and Clyde · 1 drug in this class
5. University of North Carolina, Chapel Hill · 1 drug in this class
6. University of Virginia · 1 drug in this class
7. VA Office of Research and Development · 1 drug in this class