Who are Gabapentin Enacarbil (GEn)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Gabapentin immediate release, Acetaminophen, Gabapentin, Lyrica (low dose), Neurontin, Pregabalin capsule, trazodone, pregabalin.

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Last reviewed 2026-05-17 · How we verify

Gabapentin Enacarbil (GEn) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Gabapentin Enacarbil (GEn) (Gabapentin Enacarbil (GEn)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Gabapentinoid; anticonvulsant/neuropathic pain agent. Area: Neurology.

marketed Gabapentinoid; anticonvulsant/neuropathic pain agent Voltage-gated calcium channel alpha-2-delta subunit Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Gabapentin Enacarbil (GEn) (Gabapentin Enacarbil (GEn)) — Cleveland Sleep Research Center. Gabapentin enacarbil is a prodrug of gabapentin that enhances GABA neurotransmission in the central nervous system by increasing inhibitory signaling.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Gabapentin Enacarbil (GEn) TARGET	Gabapentin Enacarbil (GEn)	Cleveland Sleep Research Center	marketed	Gabapentinoid; anticonvulsant/neuropathic pain agent	Voltage-gated calcium channel alpha-2-delta subunit
Gabapentin immediate release	Gabapentin immediate release	Theresa Zesiewicz, MD	marketed	Anticonvulsant; gabapentinoid	Voltage-gated calcium channel alpha-2-delta subunit
Acetaminophen, Gabapentin	Acetaminophen, Gabapentin	University of Saskatchewan	phase 3	Analgesic combination (non-opioid analgesic + anticonvulsant)	Prostaglandin synthesis (acetaminophen); voltage-gated calcium channel alpha-2-delta subunit (gabapentin)
Lyrica (low dose)	Lyrica (low dose)	KunWha Pharmaceutical Co., Ltd.	phase 3	Gabapentinoid; anticonvulsant; analgesic	Voltage-gated calcium channel alpha-2-delta subunit
Neurontin	gabapentin	Generic (originally Parke-Davis/Pfizer)	marketed	Gabapentinoid (anticonvulsant/neuropathic pain agent)	Large neutral amino acids transporter small subunit 1, Adenosine receptor A1, Alpha-2A adrenergic receptor	1993-12-30
Pregabalin capsule	Pregabalin capsule	Guang'anmen Hospital of China Academy of Chinese Medical Sciences	marketed	Gabapentinoid; anticonvulsant; anxiolytic	Alpha-2-delta subunit of voltage-gated calcium channels
trazodone, pregabalin	trazodone, pregabalin	Universidad de Granada	marketed	Combination anxiolytic/analgesic (serotonin antagonist and reuptake inhibitor + gabapentinoid)	5-HT2A receptor, serotonin transporter (SERT), alpha-2-delta calcium channel subunit

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Gabapentinoid; anticonvulsant/neuropathic pain agent class)

Cleveland Sleep Research Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Gabapentin Enacarbil (GEn) — Competitive Intelligence Brief. https://druglandscape.com/ci/gabapentin-enacarbil-gen. Accessed 2026-05-17.

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