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FOFLOX4 — Competitive Intelligence Brief
phase 3
Combination chemotherapy regimen
Thymidylate synthase (5-FU); DNA (oxaliplatin)
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
FOFLOX4 (FOFLOX4) — Guangdong Provincial People's Hospital. FOFLOX4 is a chemotherapy regimen combining fluorouracil, folinic acid (leucovorin), and oxaliplatin to inhibit DNA synthesis and induce apoptosis in cancer cells.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| FOFLOX4 TARGET | FOFLOX4 | Guangdong Provincial People's Hospital | phase 3 | Combination chemotherapy regimen | Thymidylate synthase (5-FU); DNA (oxaliplatin) | |
| PTH followed by dose dense AC of FEC | PTH followed by dose dense AC of FEC | Agendia | marketed | Combination chemotherapy regimen with monoclonal antibody | HER2 receptor; microtubule; DNA (topoisomerase II) | |
| CVP | CVP | SCRI Development Innovations, LLC | marketed | Combination chemotherapy regimen | ||
| FEC | FEC | Hoffmann-La Roche | marketed | Combination chemotherapy regimen | ||
| chemotherapy of mFOLFOX6 or FOLFIRI | chemotherapy of mFOLFOX6 or FOLFIRI | Xu jianmin | marketed | Combination chemotherapy regimen | Thymidylate synthase (5-FU), DNA topoisomerase I (irinotecan), DNA (oxaliplatin) | |
| CEV chemotherapy | CEV chemotherapy | Sun Yat-sen University | marketed | Combination chemotherapy regimen | ||
| SOX Chemotherapy | SOX Chemotherapy | The First Affiliated Hospital with Nanjing Medical University | marketed | Combination chemotherapy regimen |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Combination chemotherapy regimen class)
- Sun Yat-sen University · 5 drugs in this class
- Sixth Affiliated Hospital, Sun Yat-sen University · 2 drugs in this class
- Hoffmann-La Roche · 2 drugs in this class
- University Hospital, Bordeaux · 2 drugs in this class
- Beijing Friendship Hospital · 1 drug in this class
- Centre Hospitalier Universitaire Dijon · 1 drug in this class
- Amgen · 1 drug in this class
- Chungnam National University Hospital · 1 drug in this class
- AstraZeneca · 1 drug in this class
- Children's Cancer Group, China · 1 drug in this class
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Cite this brief
Drug Landscape (2026). FOFLOX4 — Competitive Intelligence Brief. https://druglandscape.com/ci/foflox4. Accessed 2026-05-13.
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