Who are Fluorouracil + folinic acid's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Xeloda, Fudr, Folic Acid, Fluorouracil Injection, 5-fluoro-uracil, tegafur-uracil.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Fluorouracil + folinic acid — Competitive Intelligence Brief

Fluorouracil + folinic acid (Fluorouracil + folinic acid) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antimetabolite chemotherapy combination. Area: Oncology.

phase 3 Antimetabolite chemotherapy combination Thymidylate synthase Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Fluorouracil + folinic acid (Fluorouracil + folinic acid) — Odense University Hospital. Fluorouracil inhibits thymidylate synthase to block DNA synthesis, while folinic acid enhances its cytotoxic effect by providing reduced folate cofactors.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Fluorouracil + folinic acid TARGET	Fluorouracil + folinic acid	Odense University Hospital	phase 3	Antimetabolite chemotherapy combination	Thymidylate synthase
Xeloda	capecitabine	Cheplapharm	marketed	Nucleoside Metabolic Inhibitor [EPC]	Thymidylate synthase	1998-01-01
Fudr	FLOXURIDINE		marketed	Antimetabolite [EPC]	Thymidylate synthase	1970-01-01
Folic Acid	FOLIC ACID	Pfizer	marketed	Vitamin C [EPC]	Thymidylate synthase	1946-01-01
Fluorouracil Injection	Fluorouracil Injection	Suzhou Suncadia Biopharmaceuticals Co., Ltd.	marketed	Antimetabolite	Thymidylate synthase
5-fluoro-uracil	5-fluoro-uracil	UNICANCER	marketed	Antimetabolite	Thymidylate synthase; RNA and DNA incorporation
tegafur-uracil	tegafur-uracil	Yokohama City University	marketed	Antimetabolite; 5-fluorouracil prodrug	Thymidylate synthase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antimetabolite chemotherapy combination class)

Asan Medical Center · 1 drug in this class
Centre Hospitalier Universitaire de Besancon · 1 drug in this class
National Health Research Institutes, Taiwan · 1 drug in this class
Odense University Hospital · 1 drug in this class
Pfizer · 1 drug in this class
Shanghai Pulmonary Hospital, Shanghai, China · 1 drug in this class
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Fluorouracil + folinic acid — Competitive Intelligence Brief. https://druglandscape.com/ci/fluorouracil-folinic-acid. Accessed 2026-05-16.

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