Extended release torsemide — Competitive Intelligence Brief

Extended release torsemide (Extended release torsemide) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Loop diuretic. Area: Cardiovascular.

phase 2 Loop diuretic NKCC2 Cardiovascular Small molecule

Target snapshot

Extended release torsemide (Extended release torsemide) — Sarfez Pharmaceuticals, Inc.. Torsemide is a loop diuretic that works by inhibiting the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle in the kidneys.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Extended release torsemide TARGET	Extended release torsemide	Sarfez Pharmaceuticals, Inc.	phase 2	Loop diuretic	NKCC2
IV loop diuretic	IV loop diuretic	NxStage Medical	marketed	Loop diuretic	Na-K-2Cl cotransporter (NKCC2)
Lasix ONYU	Lasix ONYU	University of Florida	marketed	Loop diuretic	Na-K-2Cl cotransporter (NKCC2)
torasemide-PR	torasemide-PR	Ferrer Internacional S.A.	marketed	Loop diuretic	Na-K-2Cl cotransporter (NKCC2)
IV Furosemide and PO Metolazone	IV Furosemide and PO Metolazone	Rambam Health Care Campus	marketed	Loop diuretic and thiazide-like diuretic combination	Na-K-2Cl cotransporter (NKCC2) and Na-Cl cotransporter (NCC)
Furosemide plus Chlorothiazide	Furosemide plus Chlorothiazide	Ochsner Health System	marketed	Loop diuretic + thiazide diuretic combination	Na-K-2Cl cotransporter (NKCC2) and Na-Cl cotransporter (NCC)
Furosemide dose escalation	Furosemide dose escalation	University of North Carolina, Chapel Hill	marketed	Loop diuretic	Na-K-2Cl cotransporter (NKCC2)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Loop diuretic class)

1. Sarfez Pharmaceuticals, Inc. · 3 drugs in this class
2. B&A Therapeutics · 1 drug in this class
3. Jose J Zaragoza, MD MSc · 1 drug in this class
4. Ferrer Internacional S.A. · 1 drug in this class
5. Heart Care Foundation · 1 drug in this class
6. Instituto de Investigación Sanitaria Aragón · 1 drug in this class
7. China National Center for Cardiovascular Diseases · 1 drug in this class
8. Lakeland Regional Health Systems, Inc. · 1 drug in this class
9. Larissa University Hospital · 1 drug in this class
10. Assistance Publique - Hôpitaux de Paris · 1 drug in this class