Last reviewed · How we verify
EV/DNG (Qlaira, BAY86-5027) — Competitive Intelligence Brief
phase 3
Oral contraceptive (combined estrogen-progestin)
Estrogen receptor, progesterone receptor
Contraception / Women's Health
Small molecule
Live · refreshed every 30 min
Target snapshot
EV/DNG (Qlaira, BAY86-5027) (EV/DNG (Qlaira, BAY86-5027)) — Bayer. EV/DNG is an estradiol valerate and dienogest combination oral contraceptive that prevents ovulation through hormonal suppression.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| EV/DNG (Qlaira, BAY86-5027) TARGET | EV/DNG (Qlaira, BAY86-5027) | Bayer | phase 3 | Oral contraceptive (combined estrogen-progestin) | Estrogen receptor, progesterone receptor | |
| Tibolone (Livial) | Tibolone (Livial) | Wyeth is now a wholly owned subsidiary of Pfizer | marketed | Selective tissue estrogenic activity regulator (STEAR); synthetic steroid | Estrogen receptor, progesterone receptor, androgen receptor | |
| fenofibrate and tibolone | fenofibrate and tibolone | Keogh Institute for Medical Research | marketed | Fibrate + Selective Estrogen Receptor Modulator (SERM) | PPAR-α (fenofibrate); Estrogen receptor, progesterone receptor, androgen receptor (tibolone) | |
| Ethinyl estradiol / dienogest | Ethinyl estradiol / dienogest | Helsinki University Central Hospital | marketed | Combined oral contraceptive | Estrogen receptor, progesterone receptor | |
| Oral contraceptives cyclic | Oral contraceptives cyclic | University of Athens | marketed | Hormonal contraceptive | Estrogen receptor, Progesterone receptor | |
| Tibolone plus Xiangshao granules | Tibolone plus Xiangshao granules | Peking Union Medical College Hospital | marketed | Hormone replacement therapy (HRT) / Selective tissue estrogenic activity regulator (STEAR) | Estrogen receptor, Progesterone receptor, Androgen receptor | |
| ethinyl estradiol and cyproterone acetate | ethinyl estradiol and cyproterone acetate | S.C.B. Medical College and Hospital | marketed | Combined oral contraceptive with anti-androgenic activity | Estrogen receptor, progesterone receptor, androgen receptor |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Oral contraceptive (combined estrogen-progestin) class)
- Bayer · 3 drugs in this class
- Organon and Co · 2 drugs in this class
- Teva Pharmaceuticals USA · 2 drugs in this class
- University of Colorado, Denver · 1 drug in this class
- Oregon Health and Science University · 1 drug in this class
- Helsinki University Central Hospital · 1 drug in this class
- Ironwood Pharmaceuticals, Inc. · 1 drug in this class
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Cite this brief
Drug Landscape (2026). EV/DNG (Qlaira, BAY86-5027) — Competitive Intelligence Brief. https://druglandscape.com/ci/ev-dng-qlaira-bay86-5027. Accessed 2026-05-17.
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