Who are Estrogen vaginal cream's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Mirabegron with vaginal estrogen cream, Levonorgestrel/Ethinyl Estradiol, Estradiol/norethindrone acetate, teriparatide and raloxifene, Estradiol+MPA, Clomiphene citrate and Estradiol.

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Last reviewed 2026-05-17 · How we verify

Estrogen vaginal cream — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Estrogen vaginal cream (Estrogen vaginal cream) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Estrogen replacement therapy (topical). Area: Women's Health / Gynecology.

marketed Estrogen replacement therapy (topical) Estrogen receptor alpha and beta Women's Health / Gynecology Small molecule Live · refreshed every 30 min

Target snapshot

Estrogen vaginal cream (Estrogen vaginal cream) — The University of Texas Health Science Center, Houston. Estrogen vaginal cream delivers estrogen directly to vaginal tissues to restore estrogen levels and relieve symptoms of vaginal atrophy and genitourinary syndrome of menopause.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Estrogen vaginal cream TARGET	Estrogen vaginal cream	The University of Texas Health Science Center, Houston	marketed	Estrogen replacement therapy (topical)	Estrogen receptor alpha and beta
Mirabegron with vaginal estrogen cream	Mirabegron with vaginal estrogen cream	Mackay Memorial Hospital	marketed	Beta-3 adrenergic agonist (mirabegron) + topical estrogen (vaginal cream)	Beta-3 adrenergic receptor (mirabegron); estrogen receptor alpha and beta (vaginal estrogen)
Levonorgestrel/Ethinyl Estradiol	Levonorgestrel/Ethinyl Estradiol	Wyeth is now a wholly owned subsidiary of Pfizer	marketed	Combined oral contraceptive	Progesterone receptor, estrogen receptor alpha and beta
Estradiol/norethindrone acetate	Estradiol/norethindrone acetate	Myovant Sciences GmbH	marketed	Hormone replacement therapy (HRT)	Estrogen receptor alpha and beta; progesterone receptor
teriparatide and raloxifene	teriparatide and raloxifene	Medical University of Vienna	marketed	Combination therapy: PTH analog and selective estrogen receptor modulator (SERM)	PTH1 receptor (teriparatide); estrogen receptor alpha and beta (raloxifene)
Estradiol+MPA	Estradiol+MPA	Brigham and Women's Hospital	marketed	Hormone replacement therapy (HRT)	Estrogen receptor alpha and beta; progesterone receptor
Clomiphene citrate and Estradiol	Clomiphene citrate and Estradiol	Maher elesawi kamel elesawi	marketed	Selective estrogen receptor modulator (SERM) combined with estrogen replacement	Estrogen receptor alpha and beta

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Estrogen replacement therapy (topical) class)

Medstar Health Research Institute · 1 drug in this class
The University of Texas Health Science Center, Houston · 1 drug in this class
The University of Texas Medical Branch, Galveston · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Estrogen vaginal cream — Competitive Intelligence Brief. https://druglandscape.com/ci/estrogen-vaginal-cream. Accessed 2026-05-17.

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