Who are Esketamine Nasal Spray [Spravato]'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Namenda, Felbatol, QUINIDINE, Methadone Hydrochloride, intraperitoneal nebulisation of magnesium sulphate, Ketofol 1:3 ratio.

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Last reviewed 2026-05-17 · How we verify

Esketamine Nasal Spray [Spravato] — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Esketamine Nasal Spray [Spravato] (Esketamine Nasal Spray [Spravato]) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: NMDA receptor antagonist. Area: Psychiatry.

marketed NMDA receptor antagonist NMDA receptor Psychiatry Small molecule Live · refreshed every 30 min

Target snapshot

Esketamine Nasal Spray [Spravato] (Esketamine Nasal Spray [Spravato]) — Royal North Shore Hospital. Esketamine is an NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce fast-acting antidepressant effects.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Esketamine Nasal Spray [Spravato] TARGET	Esketamine Nasal Spray [Spravato]	Royal North Shore Hospital	marketed	NMDA receptor antagonist	NMDA receptor
Namenda	MEMANTINE	AbbVie	marketed	N-methyl-D-aspartate Receptor Antagonist	Glutamate NMDA receptor; GRIN1/GRIN2A	2003-01-01
Felbatol	FELBAMATE	Mylan Speciality Lp	marketed	Anti-epileptic Agent [EPC]	NMDA receptor-ionophore complex	1993-01-01
QUINIDINE	QUINIDINE		marketed		sigma-1 receptor, NMDA receptor, CYP2D6	1950-01-01
Methadone Hydrochloride	METHADONE	Specgx Llc	marketed	Opioid Agonist	mu-opioid receptors, NMDA receptor	1947-01-01
intraperitoneal nebulisation of magnesium sulphate	intraperitoneal nebulisation of magnesium sulphate	B.P. Koirala Institute of Health Sciences	marketed	Mineral supplement / Anti-inflammatory agent	NMDA receptor (indirect antagonism); local anti-inflammatory pathways
Ketofol 1:3 ratio	Ketofol 1:3 ratio	Kasr El Aini Hospital	marketed	Anesthetic combination	NMDA receptor (ketamine); GABA-A receptor (propofol)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (NMDA receptor antagonist class)

Turku University Hospital · 3 drugs in this class
H. Lundbeck A/S · 2 drugs in this class
Ciusss de L'Est de l'Île de Montréal · 2 drugs in this class
Shalvata Mental Health Center · 2 drugs in this class
New York State Psychiatric Institute · 2 drugs in this class
Auris Medical AG · 1 drug in this class
AstraZeneca · 1 drug in this class
Alameda Health System · 1 drug in this class
Centre Hospitalier Universitaire de Nice · 1 drug in this class
Asker & Baerum Hospital · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Esketamine Nasal Spray [Spravato] — Competitive Intelligence Brief. https://druglandscape.com/ci/esketamine-nasal-spray-spravato. Accessed 2026-05-17.

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